RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Dev Biol. 2024 Dec;516:20-34. doi: 10.1016/j.ydbio.2024.07.012. Epub 2024 Jul 24.
Ectodermal organs, such as hair follicles, originate from simple epithelial and mesenchymal sheets through a complex developmental process driven by interactions between these cell types. This process involves dermal condensation, placode formation, bud morphogenesis, and organogenesis, and all of these processes require intricate interactions among various tissues. Recent research has emphasized the crucial role of reciprocal and dynamic interactions between cells and the extracellular matrix (ECM), referred to as the "dynamic duo", in the development of ectodermal organs. These interactions provide spatially and temporally changing biophysical and biochemical cues within tissues. Using the hair follicle as an example, this review highlights two types of cell-ECM adhesion units-focal adhesion-type and hemidesmosome-type adhesion units-that facilitate communication between epithelial and mesenchymal cells. This review further explores how these adhesion units, along with other cell-ECM interactions, evolve during hair follicle development and regeneration, underscoring their importance in guiding both developmental and regenerative processes.
外胚层器官，如毛囊，通过一个由这些细胞类型相互作用驱动的复杂发育过程，起源于简单的上皮和间充质片。这个过程包括真皮凝聚、基板形成、芽体形态发生和器官发生，所有这些过程都需要各种组织之间的精细相互作用。最近的研究强调了细胞和细胞外基质（ECM）之间的相互作用在表皮器官发育中的关键作用，称为“动态双元体”。这些相互作用在组织内提供空间和时间上不断变化的生物物理和生物化学线索。以毛囊为例，本综述强调了两种类型的细胞-ECM 黏附单元-粘着斑型和半桥粒型黏附单元，它们促进上皮细胞和间充质细胞之间的通信。本综述进一步探讨了这些黏附单元以及其他细胞-ECM 相互作用如何在毛囊发育和再生过程中演变，强调了它们在指导发育和再生过程中的重要性。
