Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.
Curr Probl Cardiol. 2024 Oct;49(10):102760. doi: 10.1016/j.cpcardiol.2024.102760. Epub 2024 Jul 24.
Atherosclerosis, a complex inflammatory and metabolic disorder, is the underlying cause of several life-threatening cardiovascular diseases. Stress granules (SG) are biomolecular condensates composed of proteins and mRNA that form in response to stress. Recent studies suggest a potential link between SG and atherosclerosis development. However, there remain gaps in understanding SG role in atherosclerosis development. Here we provide a thorough analysis of the role of SG in atherosclerosis, covering cellular stresses stimulation, core components, and regulatory genes in SG formation. Furthermore, we explore atherosclerosis induced factors such as inflammation, low or oscillatory shear stress (OSS), and oxidative stress (OS) may impact SG formation and then the development of atherosclerotic lesions. We have assessed how changes in SG dynamics impact pro-atherogenic processes like endothelial dysfunction, lipid metabolism, and immune cell recruitment in atherosclerosis. In summary, this review emphasizes the complex interplay between SG and atherosclerosis that could open innovative directions for targeted therapeutic strategies in preventing or treating atherosclerotic cardiovascular diseases.
动脉粥样硬化是一种复杂的炎症和代谢紊乱，是几种危及生命的心血管疾病的根本原因。应激颗粒（SG）是由蛋白质和 mRNA 组成的生物分子凝聚物，它是对压力作出反应而形成的。最近的研究表明，SG 与动脉粥样硬化的发展之间可能存在联系。然而，对于 SG 在动脉粥样硬化发展中的作用仍存在理解上的差距。在这里，我们提供了对 SG 在动脉粥样硬化中的作用的全面分析，包括 SG 形成的细胞应激刺激、核心成分和调节基因。此外，我们还探讨了动脉粥样硬化诱导因子，如炎症、低或振荡剪切应力（OSS）和氧化应激（OS），它们可能影响 SG 的形成，进而影响动脉粥样硬化病变的发展。我们评估了 SG 动力学的变化如何影响动脉粥样硬化中的促动脉粥样硬化过程，如内皮功能障碍、脂质代谢和免疫细胞募集。总之，本综述强调了 SG 与动脉粥样硬化之间的复杂相互作用，这可能为预防或治疗动脉粥样硬化性心血管疾病的靶向治疗策略开辟新的方向。
