Yang Gaowei, Wang Yiming, Guo Junfang, Rui Tao
Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, Jiangsu, 212002, People's Republic of China.
J Cardiovasc Transl Res. 2025 Apr 14. doi: 10.1007/s12265-025-10619-w.
Stress granules (SGs) are membrane-less cytoplasmic assemblies composed of mRNAs and RNA-binding proteins (RBPs) that transiently form to cope with various cellular stressors by halting mRNA translation and, consequently, protein synthesis. SG formation plays a crucial role in regulating multiple cellular processes, including cellular senescence, inflammatory responses, and adaptation to oxidative stress under both physiological and pathological conditions. Dysregulation of SG assembly and disassembly has been implicated in the pathogenesis of various diseases, including cardiovascular diseases (CVDs), cancer, viral and bacterial infections, and degenerative diseases. In this review, we survey the key aspects of SGs biogenesis and biological functions, with a particular focus on their causal involvement in CVDs. Furthermore, we summarized several SG-modulating compounds and discussed the therapeutic potential of small molecules targeting SG-related diseases in clinical settings.
应激颗粒（SGs）是由信使核糖核酸（mRNAs）和RNA结合蛋白（RBPs）组成的无膜细胞质聚集体，通过暂停mRNA翻译进而停止蛋白质合成，它们会在细胞遇到各种应激源时短暂形成。在生理和病理条件下，SG的形成在调节多种细胞过程中发挥着关键作用，包括细胞衰老、炎症反应以及对氧化应激的适应。SG组装和解聚的失调与包括心血管疾病（CVDs）、癌症、病毒和细菌感染以及退行性疾病在内的各种疾病的发病机制有关。在这篇综述中，我们概述了SG生物发生和生物学功能的关键方面，特别关注它们在CVDs中的因果关系。此外，我们总结了几种调节SG的化合物，并讨论了在临床环境中靶向SG相关疾病的小分子的治疗潜力。
