Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia.
Department of Neurology, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf Martinistraße, Hamburg, Germany.
Adv Protein Chem Struct Biol. 2024;142:421-436. doi: 10.1016/bs.apcsb.2024.03.005. Epub 2024 Jul 4.
Host-pathogen interactions are complex associations which evolve over long co-evolutionary histories. Pathogens exhibit different mechanisms to gain advantage over their host. Mimicry of host factors is an influential tool in subverting host mechanisms to ensure pathogenesis. This chapter discusses such molecular mimicry exhibited during viral infections. Understanding the evolutionary relationships, shared identity and functional impact of the virus encoded mimics is critical. With a particular emphasis on viral mimics and their association with cancer and autoimmune diseases, this chapter highlights the importance of molecular mimicry in virus biology.
宿主-病原体相互作用是一种复杂的关联，它们在漫长的共同进化历史中不断演变。病原体利用不同的机制来获得相对于宿主的优势。模拟宿主因子是颠覆宿主机制以确保发病机制的一种有影响力的工具。本章讨论了病毒感染过程中表现出的这种分子模拟。理解病毒编码模拟物的进化关系、共同特征和功能影响至关重要。特别强调病毒模拟物及其与癌症和自身免疫性疾病的关联，本章强调了分子模拟在病毒生物学中的重要性。
