Zannin Emanuela, Rigotti Camilla, Schulzke Sven M, Sindelar Richard, Werther Tobias, Lavizzari Anna, Neumann Roland P, Wallström Linda, Mosca Fabio, Ventura Maria Luisa, Dellacà Raffaele L, Veneroni Chiara
Neonatal Intensive Care Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
E. Zannin and C. Rigotti contributed equally as first authors.
Eur Respir J. 2025 Jan 2;65(1). doi: 10.1183/13993003.00246-2024. Print 2025 Jan.
This multicentre, international, retrospective study aimed to investigate whether respiratory system reactance ( ) assessed by respiratory oscillometry on day 7 of life is associated with respiratory outcomes in preterm infants below 32 weeks gestational age (GA).
Sinusoidal pressure oscillations (2-5 cmHO peak-to-peak, 10 Hz) were superimposed on the positive end-expiratory pressure. We assessed the association of z-score with the duration of respiratory support using linear regression and with bronchopulmonary dysplasia (BPD) using logistic regression. We used the likelihood ratio test to evaluate whether z-score adds significantly to clinical predictors, including GA, birthweight (BW) and the National Institute of Child Health and Human Development (NICHD) BPD prediction model.
137 infants (median (interquartile range) 28.43 (26.11-30.29) weeks GA) were included; 44 (32%) developed BPD. z-score was significantly associated with the duration of respiratory support (R=0.35). z-score was significantly higher in infants who developed BPD (p<0.001); the optimal cut-off value was 2.6, associated with 77% sensitivity and 80% specificity. In univariable analysis, per z-score increase in , the odds ratio for BPD increased by 60% and the respiratory support by 8 days. In multivariable analysis, z-score added significantly to the NICHD model and to GA and BW z-score to predict respiratory support duration (p=0.016 and p=0.014, respectively) and BPD development (p=0.003 and p<0.001, respectively).
z-score on the 7th day after birth improves the prediction of respiratory outcome in preterm infants.
这项多中心、国际性的回顾性研究旨在调查出生后第7天通过呼吸振荡法评估的呼吸系统电抗（）是否与胎龄小于32周的早产儿的呼吸结局相关。
将正弦压力振荡（峰峰值2 - 5cmH₂O，10Hz）叠加在呼气末正压上。我们使用线性回归评估电抗z评分与呼吸支持持续时间的关联，并使用逻辑回归评估与支气管肺发育不良（BPD）的关联。我们使用似然比检验来评估电抗z评分是否能显著增加对临床预测指标的预测能力，这些临床预测指标包括胎龄（GA）、出生体重（BW）和美国国立儿童健康与人类发展研究所（NICHD）的BPD预测模型。
纳入了137例婴儿（胎龄中位数（四分位间距）为28.43（26.11 -
