Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
Anticancer Res. 2024 Aug;44(8):3349-3353. doi: 10.21873/anticanres.17155.
BACKGROUND/AIM: Neskeep, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed to identify an effective anti-adhesion agent for Neskeep using rat models.
Animal experiments were performed using 60 rats, which underwent Neskeep placement on the abdominal wall. Three types of anti-adhesion agents were employed, establishing four subgroups: Seprafilm, INTERCEED, AdSpray, and only Neskeep (control) groups. Rats were sacrificed on postoperative days 7, 14, and 28 to assess adhesion levels around the Neskeep Macroscopic visual assessment with the Lauder score and histopathological evaluation were performed to assess the degree of adhesion.
There were no significant differences in the proportion of Lauder scores on days 7 and 14 between the four groups. Histological evaluation revealed no significant differences between groups at any observation time. However, the mean Lauder scores at day 28 were 5.0, 1.6, 4.0, and 4.8 in the Neskeep, Seprafilm, INTERCEED, and AdSpray groups, respectively. The proportion of milder Lauder score was significantly higher in the Seprafilm group on day 28.
Seprafilm may exhibit an anti-adhesive effect when used with Neskeep.
背景/目的：Neskeep 是一种可吸收的聚乙二醇酸间隔物，已被开发为间隔物放置手术的最佳材料。然而，防止其严重粘连是一个关键问题。因此，我们旨在使用大鼠模型确定 Neskeep 的有效防粘连剂。
对 60 只大鼠进行动物实验，在腹壁上放置 Neskeep。使用了三种类型的防粘连剂，建立了四个亚组：Seprafilm、INTERCEED、AdSpray 和仅 Neskeep（对照）组。大鼠在术后第 7、14 和 28 天处死，评估 Neskeep 周围的粘连程度。采用 Lauder 评分进行宏观视觉评估，并用组织病理学评估来评估粘连程度。
在第 7 天和第 14 天，四个组之间的 Lauder 评分比例没有显著差异。组织学评估显示，在任何观察时间点，各组之间均无显著差异。然而，在第 28 天，Neskeep、Seprafilm、INTERCEED 和 AdSpray 组的平均 Lauder 评分分别为 5.0、1.6、4.0 和 4.8。在第 28 天，Seprafilm 组的轻度 Lauder 评分比例显著更高。
Seprafilm 与 Neskeep 一起使用时可能具有防粘连作用。
