Sosa Ponce Maria Laura, Cobb Jennifer A, Zaremberg Vanina
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Trends Cell Biol. 2025 Feb;35(2):141-152. doi: 10.1016/j.tcb.2024.06.004. Epub 2024 Jul 25.
Recent studies in yeast reveal an intricate interplay between nuclear envelope (NE) architecture and lipid metabolism, and between lipid signaling and both epigenome and genome integrity. In this review, we highlight the reciprocal connection between lipids and histone modifications, which enable metabolic reprogramming in response to nutrients. The endoplasmic reticulum (ER)-NE regulates the compartmentalization and temporal availability of epigenetic metabolites and its lipid composition also impacts nuclear processes, such as transcriptional silencing and the DNA damage response (DDR). We also discuss recent work providing mechanistic insight into lipid droplet (LD) formation and sterols in the nucleus, and the collective data showing Opi1 as a central factor in both membrane sensing and transcriptional regulation of lipid-chromatin interrelated processes.
近期对酵母的研究揭示了核膜（NE）结构与脂质代谢之间，以及脂质信号传导与表观基因组和基因组完整性之间复杂的相互作用。在本综述中，我们强调了脂质与组蛋白修饰之间的相互联系，这种联系能够使细胞根据营养物质进行代谢重编程。内质网（ER）-核膜调节表观遗传代谢物的区室化和时间可用性，其脂质组成也影响核过程，如转录沉默和DNA损伤反应（DDR）。我们还讨论了最近的研究工作，这些工作为脂质滴（LD）的形成和细胞核中的固醇提供了机制性见解，以及一系列数据表明Opi1是脂质-染色质相关过程的膜感知和转录调控中的核心因子。
