Fekry Baharan, Ugartemendia Lierni, Esnaola Nestor F, Goetzl Laura
McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Division of Surgical Oncology and Gastrointestinal Surgery, Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA.
Cancers (Basel). 2024 Jul 16;16(14):2552. doi: 10.3390/cancers16142552.
This review comprehensively explores the complex interplay between extracellular vesicles (ECVs)/exosomes and circadian rhythms, with a focus on the role of this interaction in hepatocellular carcinoma (HCC). Exosomes are nanovesicles derived from cells that facilitate intercellular communication by transporting bioactive molecules such as proteins, lipids, and RNA/DNA species. ECVs are implicated in a range of diseases, where they play crucial roles in signaling between cells and their surrounding environment. In the setting of cancer, ECVs are known to influence cancer initiation and progression. The scope of this review extends to all cancer types, synthesizing existing knowledge on the various roles of ECVs. A unique aspect of this review is the emphasis on the circadian-controlled release and composition of exosomes, highlighting their potential as biomarkers for early cancer detection and monitoring metastasis. We also discuss how circadian rhythms affect multiple cancer-related pathways, proposing that disruptions in the circadian clock can alter tumor development and treatment response. Additionally, this review delves into the influence of circadian clock components on ECV biogenesis and their impact on reshaping the tumor microenvironment, a key component driving HCC progression. Finally, we address the potential clinical applications of ECVs, particularly their use as diagnostic tools and drug delivery vehicles, while considering the challenges associated with clinical implementation.
本综述全面探讨了细胞外囊泡（ECV）/外泌体与昼夜节律之间的复杂相互作用，重点关注这种相互作用在肝细胞癌（HCC）中的作用。外泌体是源自细胞的纳米囊泡，通过运输蛋白质、脂质和RNA/DNA等生物活性分子促进细胞间通讯。ECV与一系列疾病有关，它们在细胞与其周围环境之间的信号传导中发挥关键作用。在癌症背景下，已知ECV会影响癌症的发生和发展。本综述的范围扩展到所有癌症类型，综合了关于ECV各种作用的现有知识。本综述的一个独特之处在于强调外泌体的昼夜节律控制释放和组成，突出了它们作为早期癌症检测和监测转移生物标志物的潜力。我们还讨论了昼夜节律如何影响多种癌症相关途径，提出生物钟紊乱会改变肿瘤发展和治疗反应。此外，本综述深入探讨了生物钟成分对ECV生物发生的影响及其对重塑肿瘤微环境的作用，肿瘤微环境是驱动HCC进展的关键因素。最后，我们探讨了ECV的潜在临床应用，特别是它们作为诊断工具和药物递送载体的用途，同时考虑了临床实施相关的挑战。
