Soni Naveen, Bissa Bhawana
Dept. of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, India.
Dept. of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, India.
Biochimie. 2024 Dec;227(Pt A):172-181. doi: 10.1016/j.biochi.2024.07.010. Epub 2024 Jul 19.
"The environment shapes people's actions," a well-known proverb, strongly dictates that a change in our way of life changes our behavior. Circadian rhythms have been identified as a mechanism for maintaining homeostasis in the body, which, if disrupted by sleeping patterns, could result in significant metabolic alterations that adversely affect our health. The changes induced by circadian rhythm alter the secretion and cargo selection in exosomes which are nanovesicles important for intercellular communication. Exosomes were formerly known as "junk particles" but are now recognized as miniature copies of a cell's genetic material. Dysregulation of circadian rhythm has shown that it changes the gene expression of a cell to some extent and significantly alters the exosomal release. Meanwhile, cells secrete exosomes continuously to align the rhythmicity of the biological clock. In this study, we integrate circadian rhythms and exosomes with precision medicines to find better approaches to early diagnosis and treatment of disease.
“环境塑造人的行为”，这句著名的谚语有力地表明，生活方式的改变会改变我们的行为。昼夜节律已被确认为维持身体内稳态的一种机制，如果被睡眠模式打乱，可能会导致显著的代谢改变，对我们的健康产生不利影响。昼夜节律引起的变化会改变外泌体的分泌和货物选择，外泌体是对细胞间通讯很重要的纳米囊泡。外泌体以前被称为“垃圾颗粒”，但现在被认为是细胞遗传物质的微型副本。昼夜节律失调已表明，它在一定程度上会改变细胞的基因表达，并显著改变外泌体的释放。与此同时，细胞持续分泌外泌体以调整生物钟的节律性。在这项研究中，我们将昼夜节律和外泌体与精准医学相结合，以找到更好的疾病早期诊断和治疗方法。
