Porciello Giuseppe, Coluccia Sergio, Vitale Sara, Palumbo Elvira, Luongo Assunta, Grimaldi Maria, Pica Rosa, Prete Melania, Calabrese Ilaria, Cubisino Serena, Montagnese Concetta, Falzone Luca, Martinuzzo Valentina, Poletto Luigina, Rotondo Emanuela, Di Gennaro Piergiacomo, De Laurentiis Michelino, D'Aiuto Massimiliano, Rinaldo Massimo, Thomas Guglielmo, Messina Francesco, Catalano Francesca, Ferraù Francesco, Montesarchio Vincenzo, Serraino Diego, Crispo Anna, Libra Massimo, Celentano Egidio, Augustin Livia S A
Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Healthcare Direction, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Cancers (Basel). 2024 Jul 18;16(14):2576. doi: 10.3390/cancers16142576.
Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial. Dietary data were obtained from 7-day food records; HRQoL was assessed through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) and the C30 Summary Score (SumSc). Analysis of variance and multivariable linear and log-gamma regression models were performed. Mean and standard deviation for HEI-2015 score was 68.8 ± 11.2; SumSc was 81.5 ± 12.9. Women with lower HEI-2015 score had higher BMI, were more frequently exposed to tobacco smoke and had fewer years of education. Patients with a HEI-2015 score greater than 68.7 (median value) showed a significant increase in SumSc of 4% ( = 0.02). HEI-2015 components also associated with SumSc were beans and greens (β = 1.04; = 0.02). Weak associations were found for total vegetables and saturated fats. Higher diet quality in breast cancer survivors was associated with higher overall HRQoL in this cross-sectional analysis.
健康相关生活质量（HRQoL）是癌症患者最关注的方面之一。健康饮食指数（HEI）是一种先验饮食质量指数，与北美人群癌症幸存者的健康结果和HRQoL直接相关。我们在一项DEDiCa生活方式试验中招募的492名乳腺癌女性中，评估了地中海人群中HEI - 2015与HRQoL之间的基线关联。饮食数据来自7天的食物记录；HRQoL通过欧洲癌症研究与治疗组织生活质量问卷核心30（EORTC QLQ C30）和C30总结评分（SumSc）进行评估。进行了方差分析以及多变量线性和对数伽马回归模型分析。HEI - 2015评分的平均值和标准差分别为68.8±11.2；SumSc为81.5±12.9。HEI - 2015评分较低的女性体重指数较高，更频繁地接触烟草烟雾，受教育年限较少。HEI - 2015评分大于68.7（中位数）的患者SumSc显著增加4%（P = 0.02）。与SumSc相关的HEI - 2015成分还有豆类和绿叶蔬菜（β = 1.04；P = 0.02）。在总蔬菜和饱和脂肪方面发现了较弱的关联。在这项横断面分析中，乳腺癌幸存者较高的饮食质量与较高的总体HRQoL相关。
