抗疟药。1. 作为潜在抗疟药的α-山道年衍生的环过氧化物。
Antimalarial agents. 1. alpha-Santonin-derived cyclic peroxide as potential antimalarial agent.
作者信息
Tani S, Fukamiya N, Kiyokawa H, Musallam H A, Pick R O, Lee K H
出版信息
J Med Chem. 1985 Nov;28(11):1743-4. doi: 10.1021/jm00149a034.
PMID:3906128
Abstract
An alpha-santonin-derived cyclic peroxide (7) related to qinghaosu (1) has been synthesized and tested for antimalarial activity in vitro against the chloroquine-resistant (Smith) isolates of Plasmodium falciparum as well as in vivo against Plasmodium berghei in mice and was found to be devoid of activity.
摘要
一种与青蒿素（1）相关的源自山道年的环过氧化物（7）已被合成，并在体外针对恶性疟原虫氯喹抗性（史密斯）分离株进行了抗疟活性测试，以及在体内针对小鼠伯氏疟原虫进行了测试，结果发现其没有活性。
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