Fröschen Frank Sebastian, Kitkowski Pia Maria, Strauß Andreas Christian, Molitor Ernst, Hischebeth Gunnar Thorben Rembert, Franz Alexander
Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Antibiotics (Basel). 2024 Jul 19;13(7):671. doi: 10.3390/antibiotics13070671.
Spondylodiscitis is a severe spinal infection that requires an effective antibiotic treatment. Therefore, we sought to analyse the causative pathogens from intraoperative specimen in patients with spondylodiscitis and a need for surgery. To this end, we performed a retrospective study of all patients with spondylodiscitis and a need for operative treatment admitted to our hospital between January 2020 and December 2022. A total of 114 cases with spondylodiscitis were identified. A total of 120 different pathogens were detected. Overall, 76.7% of those microorganisms were Gram-positive bacteria. The most common causative pathogen was ( = 32; 26.6%), followed by coagulase-negative staphylococci ( = 28; 23.4%), of which ( = 18; 15%) was the most frequently detected, as well as enterococci ( = 10; 8.4%) and spp. ( = 11; 9.2%). Moreover, 19.1% ( = 22) and 3.4% ( = 4) of all detected isolates were Gram-negative pathogens or fungi, respectively. Overall, 42.8% of all coagulase-negative staphylococci were oxacillin-resistant, while none of them were vancomycin-resistant. In summary, 50% of the pathogens could be identified as staphylococci. The results of our study highlight the important burden of oxacillin-resistant Gram-positive bacteria as an aetiological cause of spondylodiscitis, providing a relevant finding for antimicrobial stewardship programmes.
脊椎椎间盘炎是一种严重的脊柱感染，需要有效的抗生素治疗。因此，我们试图分析脊椎椎间盘炎且需要手术治疗患者术中标本的致病病原体。为此，我们对2020年1月至2022年12月期间我院收治的所有脊椎椎间盘炎且需要手术治疗的患者进行了一项回顾性研究。共确定了114例脊椎椎间盘炎病例。共检测到120种不同的病原体。总体而言，这些微生物中有76.7%为革兰氏阳性菌。最常见的致病病原体是[具体菌种1]（n = 32；26.6%），其次是凝固酶阴性葡萄球菌（n = 28；23.4%），其中[具体菌种2]（n = 18；15%）是最常检测到的，还有肠球菌（n = 10；8.4%）和[其他菌种]（n = 11；9.2%）。此外，所有检测分离株中分别有19.1%（n = 22）和3.4%（n = 4）为革兰氏阴性病原体或真菌。总体而言，所有凝固酶阴性葡萄球菌中有42.8%对苯唑西林耐药，而它们均对万古霉素不耐药。总之，50%的病原体可鉴定为葡萄球菌。我们的研究结果突出了耐苯唑西林革兰氏阳性菌作为脊椎椎间盘炎病因的重要负担，为抗菌药物管理计划提供了相关发现。
