Hassen Hayfa Ben Haj, Ammar Achraf, Machfer Amal, Fkih Nadia, Erriahi Siwar, Hamdi Sirine, Chtourou Hamdi, Bouzid Mohamed Amine
Research Laboratory Education, Motricity, Sport and Health, EM2S, LR19JS01, University of Sfax, Sfax 3000, Tunisia.
Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.
Brain Sci. 2024 Jul 13;14(7):701. doi: 10.3390/brainsci14070701.
Patients with end stage renal disease (ESRD) display many cognitive and physiological alterations resulting from renal failure and physical inactivity. Caffeine intake has been reported to improve cognitive/physical performance in several studies. However, whether the benefits of caffeine intake apply to patients with ESRD remains unknown. The aim of the present study was to explore the effect of caffeine intake on postural balance, cognitive function and functional capacity in patients with ESRD. In a randomized order, 12 patients with ESRD (age: 33.85 ± 8.57 years; Female: 45.5%) performed a battery of tests after either caffeine (CF) (400 mg) or placebo (PLA) ingestion. Postural balance was evaluated using a stabilometric platform. Functional capacity was assessed with the sit-to-stand and up-and-go tests, and for cognitive performances, reaction time test and a vigilance test were used. Results showed a significant improvement in up-and-go test ( = 0.01) and sit-to-stand test performances with CF compared to PLA ( < 0.01). Time of reaction test and vigilance test ( < 0.01) performances were significantly higher with CF. No significant difference was observed in postural balance between CF and PLA. The results of this study suggest that acute caffeine ingestion positively enhances cognitive function and functional capacity in patients with ESRD.
终末期肾病（ESRD）患者表现出许多由肾衰竭和身体活动不足导致的认知和生理改变。多项研究报道，摄入咖啡因可改善认知/身体表现。然而，摄入咖啡因的益处是否适用于ESRD患者仍不清楚。本研究的目的是探讨摄入咖啡因对ESRD患者姿势平衡、认知功能和功能能力的影响。12名ESRD患者（年龄：33.85±8.57岁；女性：45.5%）以随机顺序在摄入咖啡因（CF）（400毫克）或安慰剂（PLA）后进行了一系列测试。使用稳定测量平台评估姿势平衡。通过坐立试验和起身行走试验评估功能能力，对于认知表现，使用反应时间测试和警觉性测试。结果显示，与PLA相比，CF组的起身行走试验（P = 0.01）和坐立试验表现有显著改善（P < 0.01）。CF组的反应时间测试和警觉性测试表现（P < 0.01）显著更高。CF组和PLA组在姿势平衡方面未观察到显著差异。本研究结果表明，急性摄入咖啡因可积极增强ESRD患者的认知功能和功能能力。
