Makani Punitkumar, Thioux Marc, Koops Elouise A, Pyott Sonja J, van Dijk Pim
Department of Otorhinolaryngology-Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands.
Brain Sci. 2024 Jul 19;14(7):726. doi: 10.3390/brainsci14070726.
Recent evidence suggests a connection between hyperacusis and the motor system of the brain. For instance, our recent study reported that hyperacusis in participants with tinnitus and hearing loss is associated with smaller gray matter volumes in the supplementary motor area (SMA). Given that hearing loss can affect gray matter changes in tinnitus, this study aimed to determine if the changes reported in our previous findings of smaller SMA gray matter volumes in hyperacusis persist in the absence of hearing loss. Data for this study were gathered from four prior studies conducted between 2004 and 2019 at the University Medical Centre Groningen (UMCG). A total of 101 participants with tinnitus and either clinically normal hearing (normal hearing with tinnitus or NHT, n = 35) or bilateral sensorineural hearing loss (hearing loss with tinnitus or HLT, n = 66) were included across four studies. Hyperacusis was determined by a score of ≥22 on the Hyperacusis Questionnaire (HQ). In the NHT group, 22 (63%) participants scored ≥22 on the HQ (NHT with hyperacusis: mean age 44.1 years, 12 females), while in the HLT group, 25 (38%) participants scored ≥22 on the HQ (HLT with hyperacusis: mean age 59.5 years, 10 females). The 2 × 2 between-group ANOVAs revealed that hyperacusis is associated with smaller SMA gray matter volumes, regardless of hearing levels. Notably, the smaller SMA gray matter volumes in hyperacusis were primarily influenced by the attentional subscales of the HQ. The association between hyperacusis and the motor system may indicate a constant alertness to sounds and a readiness for motor action.
近期证据表明，听觉过敏与大脑运动系统之间存在联系。例如，我们最近的研究报告称，患有耳鸣和听力损失的参与者的听觉过敏与辅助运动区（SMA）较小的灰质体积有关。鉴于听力损失会影响耳鸣患者的灰质变化，本研究旨在确定在没有听力损失的情况下，我们之前关于听觉过敏患者SMA灰质体积较小的研究结果中所报告的变化是否依然存在。本研究的数据来自2004年至2019年在格罗宁根大学医学中心（UMCG）进行的四项先前研究。四项研究共纳入了101名患有耳鸣且听力临床正常（耳鸣伴正常听力或NHT，n = 35）或双侧感音神经性听力损失（耳鸣伴听力损失或HLT，n = 66）的参与者。听觉过敏通过听觉过敏问卷（HQ）得分≥22来确定。在NHT组中，22名（63%）参与者HQ得分≥22（伴有听觉过敏的NHT：平均年龄44.1岁，12名女性），而在HLT组中，25名（38%）参与者HQ得分≥22（伴有听觉过敏的HLT：平均年龄59.5岁，10名女性）。组间2×2方差分析显示，无论听力水平如何，听觉过敏都与较小的SMA灰质体积有关。值得注意的是，听觉过敏患者较小的SMA灰质体积主要受HQ注意力子量表的影响。听觉过敏与运动系统之间的关联可能表明对声音持续保持警觉并随时准备采取运动行动。
