Shulskaya Marina V, Semenova Ekaterina I, Rudenok Margarita M, Partevian Suzanna A, Lukashevich Maria V, Karabanov Alexei V, Fedotova Ekaterina Yu, Illarioshkin Sergey N, Slominsky Petr A, Shadrina Maria I, Alieva Anelya Kh
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center "Kurchatov Institute", Kurchatova pl., 2, Moscow 123082, Russia.
Federal State Scientific Institution, Scientific Center of Neurology, Russian Academy of Sciences (RAS), Volokolamskoye sh., 80, Moscow 125367, Russia.
Biomedicines. 2024 Jun 23;12(7):1391. doi: 10.3390/biomedicines12071391.
Parkinson's disease (PD) is one of the most common human neurodegenerative diseases. Belated diagnoses of PD and late treatment are caused by its elongated prodromal phase. Thus, searching for new candidate genes participating in the development of the pathological process in the early stages of the disease in patients who have not yet received therapy is relevant. Changes in mRNA and protein levels have been described both in the peripheral blood and in the brain of patients with PD. Thus, analysis of changes in the mRNA expression in peripheral blood is of great importance in studying the early stages of PD. This work aimed to analyze the changes in , , , and gene expression in the peripheral blood of patients in the early stages of PD. We found a statistically relevant and PD-specific change in the expression of the gene, indicating a disruption in the processes of neuronal regeneration and the functioning of synapses. The data obtained during the study indicate that this gene can be considered a potential biomarker of the early stages of PD.
帕金森病（PD）是人类最常见的神经退行性疾病之一。其前驱期较长导致PD诊断延迟和治疗较晚。因此，在尚未接受治疗的患者中寻找参与疾病早期病理过程发展的新候选基因具有重要意义。PD患者外周血和大脑中的mRNA和蛋白质水平均有变化。因此，分析外周血中mRNA表达的变化对于研究PD的早期阶段至关重要。这项工作旨在分析PD早期患者外周血中、、、和基因表达的变化。我们发现基因表达存在统计学上相关且特定于PD的变化，表明神经元再生过程和突触功能受到破坏。研究期间获得的数据表明，该基因可被视为PD早期阶段的潜在生物标志物。
