Djibougou Diakourga Arthur, Mensah Gloria Ivy, Kaboré Achille, Toé Inoussa, Sawadogo Leon Tinnoga, Lompo Palpouguini Felix, Kone Amariane M M, Hien Hervé, Meda Clement Ziemlé, Combary Adjima, Bonfoh Bassirou, Addo Kennedy Kwasi, Belem Adrien Marie-Gaston, Dabiré Roch Konbobr, Hoffmann Jonathan, Perreau Matthieu, Diagbouga Potiandi Serge
Doctoral School of Natural Sciences and Agronomy, Université Nazi BONI, Bobo-Dioulasso 1091, Burkina Faso.
Infectious Diseases Program, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso 1091, Burkina Faso.
Biomedicines. 2024 Jul 3;12(7):1472. doi: 10.3390/biomedicines12071472.
The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 ( = 82), as control, were participants without helminthic or complex infection (-/Helm-), group 2 ( = 73) were TB patients without helminthic infection (+/Helm-), and group 3 ( = 22) were TB patients with helminthic infection (+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the complex (+/Helm+) compared to the other groups ( < 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups ( > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the /Helm+ and /Helm- patients. Exploring these types of immune-haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis-helminthiasis coinfection.
蠕虫病对宿主免疫的影响是一个被忽视的研究领域，尤其是在结核病（TB）感染方面。本研究旨在评估蠕虫病对博博迪乌拉索新诊断结核病患者免疫和血液学参数的影响。在所有生物学分析之后，我们形成了三个亚组：第1组（n = 82）作为对照组，是没有蠕虫或混合感染的参与者（-/Helm-），第2组（n = 73）是没有蠕虫感染的结核病患者（+/Helm-），第3组（n = 22）是有蠕虫感染的结核病患者（+/Helm+）。结核病患者中蠕虫合并感染的比例为23.16%（22/95），本研究中观察到的蠕虫病病例中有77.3%（17/22）发现有混合感染。与其他组相比，低CD4 T细胞计数和低CD4:CD8比值与蠕虫和混合感染（+/Helm+）显著相关（P < 0.05）。然而，三个参与组之间的CD8中位数没有统计学显著差异（P > 0.05）。淋巴细胞减少、单核细胞增多、血小板增多和低色素小细胞性贫血是在+/Helm+和+/Helm-患者中观察到的血液学缺陷。探索这些类型的免疫血液学生物标志物将有助于诊断以及更好地随访和监测结核病-蠕虫病合并感染。
