Celik Kiymet, Ozkan Zarif Nurten, Ozen Kucukcetin Ikbal, Arayici Sema, Kihtir Zeynep, Unver Tuhan Hale, Ongun Hakan
Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.
Medical Biochemistry Laboratory, Akdeniz University, 07070 Antalya, Turkey.
Children (Basel). 2024 Jun 25;11(7):771. doi: 10.3390/children11070771.
Perilipin 2 (PLIN2) is a protein that contributes to the formation and stability of lipid droplets. It has been associated with the development of several diseases, particularly related to glucose and lipid metabolism. In infants of diabetic mother (IDM), fetal hyperinsulinaemia leads to increased adipose tissue and macrosomia. The aim of this study was to investigate the relationship between PLIN2 levels and anthropometric measurements in the IDM and to investigate the relationship between PLIN2 levels and IGF-1, IGF-2 and leptin levels.
The study group consisted of IDMs, while the control group consisted of infants born to non-diabetic mother, matched for gestational week and gender. Cord blood samples were collected from all patients to determine PLIN2, IGF-1, IGF-2 and leptin levels. Anthropometric measurements were taken for all patients at birth.
There were no differences between the groups in birth weight, birth length, head circumference and body mass index (BMI), but middle arm circumference, triceps, biceps, subscapular and suprailiac skinfold thickness were significantly higher in the IDM. While PLIN2, IGF-1, IGF-2 and leptin levels were similar between groups, there was a strong correlation between PLIN2 levels and IGF-2 and leptin levels.
Even if IDMs were not macrosomic, the presence of high subcutaneous adipose tissue was not associated with PLIN2.
脂滴包被蛋白2（PLIN2）是一种有助于脂滴形成和稳定的蛋白质。它与多种疾病的发生有关，特别是与糖脂代谢相关。在糖尿病母亲的婴儿（IDM）中，胎儿高胰岛素血症会导致脂肪组织增加和巨大儿。本研究的目的是调查IDM中PLIN2水平与人体测量指标之间的关系，并研究PLIN2水平与胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子-2（IGF-2）和瘦素水平之间的关系。
研究组由IDM组成，对照组由孕周和性别匹配的非糖尿病母亲所生婴儿组成。采集所有患者的脐血样本以测定PLIN2、IGF-1、IGF-2和瘦素水平。在所有患者出生时进行人体测量。
两组在出生体重、出生身长、头围和体重指数（BMI）方面无差异，但IDM的上臂中部周长、肱三头肌、肱二头肌、肩胛下和髂上皮肤褶厚度明显更高。虽然两组之间的PLIN2、IGF-1、IGF-2和瘦素水平相似，但PLIN2水平与IGF-2和瘦素水平之间存在很强的相关性。
即使IDM不是巨大儿，皮下脂肪组织含量高也与PLIN2无关。
