Ferrara Isabella R, Sadowsky Cristina L
International Center for Spinal Cord Injury, Kennedy Krieger Institute, Baltimore, MD 21205, USA.
Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Children (Basel). 2024 Jul 3;11(7):815. doi: 10.3390/children11070815.
This systematic review aims to investigate the relationship between muscle mass and specific health outcomes in pediatric populations with neuromuscular disorders. A search was performed for any relevant studies published in English from 1996 to 2023 in five databases. To be included in this analysis, articles must have had participants with an average age ≤21, focus on children with neuromuscular disabilities, and primarily examine relationships between muscle mass and any functional or health outcomes measure. Studies including typically developing children were used to contrast and enhance findings. Thirty-two studies were included, with 10,129 unique individuals represented: seventeen studies focused on healthy/typically developing children; seven on children with cerebral palsy; three on children with Duchenne muscular dystrophy; two on children with sarcopenia; and one study each on children with osteoporosis, congenital muscular dystrophy, and other various neurologic disorders. Thirteen studies assessed functional outcomes, ten assessed bone outcomes, and nine assessed other cardiovascular/metabolic outcomes. All of the included studies demonstrated relationships between muscle mass and respective outcomes in varying measures. The results of this review demonstrate that there is a consistently recognized relationship between muscle mass and important health outcomes in children, supporting clinically targeting muscle mass as a means to optimize desired outcomes.
本系统评价旨在研究神经肌肉疾病患儿群体中肌肉量与特定健康结局之间的关系。在五个数据库中检索了1996年至2023年以英文发表的任何相关研究。要纳入本分析，文章的参与者平均年龄必须≤21岁，关注神经肌肉残疾儿童，并主要研究肌肉量与任何功能或健康结局指标之间的关系。纳入发育正常儿童的研究用于对比和强化研究结果。共纳入32项研究，涉及10129名个体：17项研究关注健康/发育正常儿童；7项关注脑瘫儿童；3项关注杜氏肌营养不良症儿童；2项关注肌肉减少症儿童；另有1项研究分别针对骨质疏松症儿童、先天性肌营养不良症儿童和其他各种神经系统疾病儿童。13项研究评估了功能结局，10项评估了骨骼结局，9项评估了其他心血管/代谢结局。所有纳入研究均表明肌肉量与各自结局之间存在不同程度的关联。本评价结果表明，儿童的肌肉量与重要健康结局之间存在一直被认可的关系，支持临床上将肌肉量作为优化预期结局的一种手段。
