Sadowsky Cristina L
International Center for Spinal Cord Injury, Kennedy Krieger Institute, Baltimore, MD 21205, USA.
Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Children (Basel). 2023 May 5;10(5):837. doi: 10.3390/children10050837.
Muscle loss is consistently associated with immobility and paralysis and triggers significant metabolic and functional changes. The negative effects of sarcopenia are amplified in children who are in the process of building their muscle mass as part of development. Because muscle mass loss is consistently associated with increased morbidity and mortality throughout life, optimizing the size and health of muscles following a neurologic injury is an objective target for therapeutic interventions. This review hypothesizes that muscle mass correlates with functional outcomes in children with paralysis related to spinal cord-related neurologic deficits. We propose that the measurement of muscle mass in this population can be used as an objective outcome for clinical long-term care. Finally, some practical clinical approaches to improving muscle mass are presented.
肌肉流失一直与活动受限和瘫痪相关，并引发显著的代谢和功能变化。肌肉减少症的负面影响在正处于生长发育阶段、肌肉量不断增加的儿童中会被放大。由于肌肉量减少在人的一生中始终与发病率和死亡率的增加相关，因此在神经损伤后优化肌肉的大小和健康状况是治疗干预的一个客观目标。本综述假设，肌肉量与因脊髓相关神经功能缺损而瘫痪的儿童的功能预后相关。我们提出，测量这一人群的肌肉量可作为临床长期护理的一个客观指标。最后，本文介绍了一些改善肌肉量的实际临床方法。
