Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Campus de Sescelades, 43007 Tarragona, Spain.
Laboratory of Metabolism and Obesity, Vall d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Int J Mol Sci. 2024 Jul 14;25(14):7713. doi: 10.3390/ijms25147713.
This study investigated the influence of photoperiod (day length) on the efficacy of grape seed proanthocyanidin extract (GSPE) in mitigating metabolic disorders in obese rats fed a cafeteria diet. Rats were exposed to standard (L12), long (L18), or short (L6) photoperiods and treated with GSPE or vehicle. In the standard photoperiod, GSPE reduced body weight gain (50.5%), total cholesterol (37%), and triglycerides (34.8%), while increasing the expression of hepatic metabolic genes. In the long photoperiod, GSPE tended to decrease body weight gain, increased testosterone levels (68.3%), decreased liver weight (12.4%), and decreased reverse serum amino acids. In the short photoperiod, GSPE reduced glycemia (~10%) and lowered triglyceride levels (38.5%), with effects modified by diet. The standard photoperiod showed the greatest efficacy against metabolic syndrome-associated diseases. The study showed how day length affects GSPE's benefits and underscores considering biological rhythms in metabolic disease therapies.
本研究调查了光周期（日照长度）对葡萄籽原花青素提取物（GSPE）减轻 cafeteria 饮食喂养肥胖大鼠代谢紊乱疗效的影响。大鼠暴露于标准（L12）、长（L18）或短（L6）光周期，并接受 GSPE 或载体处理。在标准光周期下，GSPE 降低了体重增加（50.5%）、总胆固醇（37%）和甘油三酯（34.8%），同时增加了肝脏代谢基因的表达。在长光周期下，GSPE 倾向于降低体重增加，增加睾丸激素水平（68.3%），降低肝重（12.4%），并降低血清氨基酸的逆转。在短光周期下，GSPE 降低了血糖（~10%）并降低了甘油三酯水平（38.5%），其作用受饮食影响。标准光周期对代谢综合征相关疾病的疗效最大。该研究表明了日照长度如何影响 GSPE 的益处，并强调了在代谢疾病治疗中考虑生物节律的重要性。
