近年来关于 RNA 结合蛋白在骨骼发育和疾病中的研究进展。
Recent Progress in the Research on RNA-Binding Proteins in Bone Development and Diseases.
机构信息
Laboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
出版信息
Int J Mol Sci. 2024 Jul 15;25(14):7735. doi: 10.3390/ijms25147735.
RNA-binding proteins (RBPs), which regulate gene expression through post-transcriptional modifications of RNAs, play a role in diverse biological processes that include bone cell development and bone tissue formation. RBP dysregulation may result in aberrant bone homeostasis and contribute to various bone diseases. The function of RBPs in bone physiology and pathophysiology and the underlying molecular mechanisms have been extensively studied in recent years. This article provides a review of such studies, highlighting the potential of RBPs as pivotal targets for therapeutic intervention.
RNA 结合蛋白（RBPs）通过 RNA 的转录后修饰来调节基因表达，在包括骨细胞发育和骨组织形成在内的多种生物学过程中发挥作用。RBP 失调可能导致异常的骨内稳态，并导致各种骨骼疾病。近年来，RBPs 在骨生理学和病理生理学中的作用及其潜在的分子机制已得到广泛研究。本文综述了这些研究，强调了 RBPs 作为治疗干预的关键靶点的潜力。
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