Ceara Institute of Science and Technology (IFCE), Sobral 62042-030, Brazil.
Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
Int J Mol Sci. 2024 Jul 15;25(14):7729. doi: 10.3390/ijms25147729.
For many years, it has been speculated that elevated testosterone levels may be critically involved in the genesis and proliferation of prostate cancer.
The effect of testosterone on the metabolic activity of hormone-independent [PC-3] and hormone-dependent [LNCAP] cancer cells was investigated in vitro. Additionally, the impact of testosterone nanoemulsion [nanocare] on cell viability was accessed by flow cytometry.
Despite the dependency of the normal prostate and of most prostatic cancers upon androgens, the obtained results indicate that, contrary to prevailing opinion, the supplementation of testosterone with higher doses in nanoemulsion was able to lower the metabolic activity and viability of prostate cancer cells.
We conclude that the growth of hormone-independent and hormone-dependent prostate cancer cells was reduced by the exposure of a nanoemulsion of bioidentical testostosterone in vitro. To the best of our knowledge, this is the first time that the potential effect of a testosterone nanoemulsion on the metabolic activity of prostate cancer cells has been shown. Such tests suggest that the growth of hormone-independent and hormone-dependent prostate cancer cells was reduced by the administration of bioidentical testostosterone, and this might be an interesting strategy for prostate cancer treatment in diagnosed patients.
多年来，人们推测升高的睾酮水平可能在前列腺癌的发生和增殖中起着关键作用。
我们在体外研究了睾酮对激素非依赖性[PC-3]和激素依赖性[LNCAP]癌细胞代谢活性的影响。此外，还通过流式细胞术评估了睾酮纳米乳[nanocare]对细胞活力的影响。
尽管正常前列腺和大多数前列腺癌依赖于雄激素，但研究结果表明，与普遍观点相反，用纳米乳补充更高剂量的睾酮能够降低前列腺癌细胞的代谢活性和活力。
我们的结论是，激素非依赖性和激素依赖性前列腺癌细胞的生长在体外暴露于生物等同睾酮纳米乳后减少。据我们所知，这是首次显示生物等同睾酮纳米乳对前列腺癌细胞代谢活性的潜在影响。这些测试表明，给予生物等同睾酮可降低激素非依赖性和激素依赖性前列腺癌细胞的生长，这可能是确诊患者前列腺癌治疗的一种有趣策略。
