Laboratory of Water and Environment, Faculty of Technology, University Hassiba Benbouali of Chlef, Chlef 02000, Algeria.
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 700050 Iasi, Romania.
Int J Mol Sci. 2024 Jul 17;25(14):7839. doi: 10.3390/ijms25147839.
Adding carbonyl groups into the hydrogel matrix improves the stability and biocompatibility of the hydrogels, making them suitable for different biomedical applications. In this review article, we will discuss the use of hydrogels based on polysaccharides modified by oxidation, with particular attention paid to the introduction of carbonyl groups. These hydrogels have been developed for several applications in tissue engineering, drug delivery, and wound healing. The review article discusses the mechanism by which oxidized polysaccharides can introduce carbonyl groups, leading to the development of hydrogels through cross-linking with proteins. These hydrogels have tunable mechanical properties and improved biocompatibility. Hydrogels have dynamic properties that make them promising biomaterials for various biomedical applications. This paper comprehensively analyzes hydrogels based on cross-linked proteins with carbonyl groups derived from oxidized polysaccharides, including microparticles, nanoparticles, and films. The applications of these hydrogels in tissue engineering, drug delivery, and wound healing are also discussed.
向水凝胶基质中添加羰基基团可以提高水凝胶的稳定性和生物相容性，使其适用于不同的生物医学应用。在这篇综述文章中，我们将讨论基于多糖氧化修饰的水凝胶的应用，特别关注引入羰基基团的情况。这些水凝胶已被开发用于组织工程、药物输送和伤口愈合等多个领域。本文讨论了氧化多糖如何通过与蛋白质交联来引入羰基基团，从而开发出水凝胶的机制。这些水凝胶具有可调节的机械性能和改善的生物相容性。水凝胶具有动态特性，使其成为各种生物医学应用有前途的生物材料。本文全面分析了基于交联蛋白质的水凝胶，这些蛋白质的羰基基团来源于氧化多糖，包括微球、纳米颗粒和薄膜。还讨论了这些水凝胶在组织工程、药物输送和伤口愈合方面的应用。
