Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil.
Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Int J Environ Res Public Health. 2024 Jun 23;21(7):821. doi: 10.3390/ijerph21070821.
Atmospheric pollution can be defined as a set of changes that occur in the composition of the air, making it unsuitable and/or harmful and thereby generating adverse effects on human health. The regular practice of physical exercise (PE) is associated with the preservation and/or improvement of health; however, it can be influenced by neuroimmunoendocrine mechanisms and external factors such as air pollution, highlighting the need for studies involving the practice of PE in polluted environments. Herein, 24 male C57BL/6 mice were evaluated, distributed into four groups (exposed to a high concentration of pollutants/sedentary, exposed to a high concentration of pollutants/exercised, exposed to ambient air/sedentary, and exposed to ambient air/exercised). The exposure to pollutants occurred in the environmental particle concentrator (CPA) and the physical training was performed on a treadmill specially designed for use within the CPA. Pro- and anti-inflammatory markers in blood and bronchoalveolar lavage (BALF), BALF cellularity, and lung tissue were evaluated. Although the active group exposed to a high concentration of pollution showed a greater inflammatory response, both the correlation analysis and the ratio between pro- and anti-inflammatory cytokines demonstrated that the exercised group presented greater anti-inflammatory activity, suggesting a protective/adaptative effect of exercise when carried out in a polluted environment.
大气污染可定义为空气中发生的一系列变化，使其变得不适宜和/或有害，并由此对人类健康产生不利影响。定期进行体育锻炼（PE）与保持和/或改善健康有关；然而，它可能会受到神经免疫内分泌机制和空气污染等外部因素的影响，突出了在污染环境中进行 PE 实践的研究的必要性。在此，评估了 24 只雄性 C57BL/6 小鼠，将其分为四组（暴露于高浓度污染物/久坐、暴露于高浓度污染物/运动、暴露于环境空气/久坐和暴露于环境空气/运动）。污染物暴露发生在环境颗粒浓缩器（CPA）中，而体能训练是在专门为在 CPA 内使用而设计的跑步机上进行的。评估了血液和支气管肺泡灌洗液（BALF）、BALF 细胞计数和肺组织中的促炎和抗炎标志物。尽管暴露于高浓度污染的活跃组表现出更强的炎症反应，但相关性分析和促炎与抗炎细胞因子的比例均表明，运动组表现出更强的抗炎活性，表明在污染环境中进行运动具有保护/适应作用。
