Up to 1.6 million tons of waste is produced annually by each of more than 21,000 concentrated animal feeding operations (CAFOs) located in the United States (USA). These operations give rise to externalities, including adverse local and global health impacts from CAFO waste emissions, which can potentially outweigh their economic viability. However, a shortage of evidence synthesis research exclusively on the impacts of USA-based CAFO waste emissions may hinder effective policy development. This scoping review (ScR) study, adhering to the guidelines from the Joanna Briggs Institute, conducted a search in databases including Scopus, Web of Science, PubMed, and Embase in May 2020, resulting in ten publications that met the inclusion criteria. The results suggest possible exposure of CAFO workers to multidrug-resistant (MDRSA), campylobacteriosis, and cryptosporidiosis. Communities near CAFOs experienced higher rates of adverse health impacts compared to those in non-CAFO areas, with patterns suggesting that proximity may correlate with increased odds of detrimental health effects. Implicit global health threats include methicillin-resistant (MRSA), MDRSA, campylobacteriosis, tuberculosis, and cryptosporidiosis. These studies provide foundational insights into CAFO proximity, density patterns, and adverse public health effects, indicating a need for evidence-informed environmental health policies to minimize local and global risks.