Kosanovic Djuro, Avdeev Sergey N, Milovanov Andrey P, Chernyaev Andrey L
Department of Pulmonology, I. M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Laboratory of Pathology of Reproduction, A. P. Avtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Life (Basel). 2024 Jul 13;14(7):875. doi: 10.3390/life14070875.
Northern pulmonary hypertension (NPH) is a medical condition that is still enigmatic in non-Russian-speaking countries. The extant previous literature is mostly available in the Russian language and, therefore, not accessible to the rest of the world. The recent increased interest in climate changes and environmental effects on pulmonary circulation prompted us to summarize the knowledge from the past about the effects of cold on pulmonary vasculature. In this review, we, for the first time, describe, in detail, the pathological attributes of human NPH, a medical disorder that occurs in people living in extremely cold regions, in the English language. Briefly, NPH is characterized by the hyper-muscularization of the pulmonary arteries and de novo muscularization of the arterioles with the ultimate development of right ventricular hypertrophy. However, the profound molecular mechanisms of the NPH pathology are to be revealed in future comprehensive studies.
北部肺动脉高压（NPH）是一种在非俄语国家仍不为人知的病症。先前的现有文献大多是俄语的，因此世界其他地区无法获取。最近，人们对气候变化和环境对肺循环的影响越来越感兴趣，这促使我们总结过去关于寒冷对肺血管系统影响的知识。在这篇综述中，我们首次用英语详细描述了人类NPH的病理特征，这是一种发生在生活在极寒地区人群中的医学病症。简而言之，NPH的特征是肺动脉肌层肥厚和小动脉新生肌化，并最终发展为右心室肥大。然而，NPH病理的深层分子机制有待未来的全面研究揭示。
