Cheng Chun-Gu, Su Sheng-Hua, Chien Wu-Chien, Chen Ryan, Chung Chi-Hsiang, Cheng Chun-An
Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 32549, Taiwan.
Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Life (Basel). 2024 Jul 19;14(7):903. doi: 10.3390/life14070903.
(1) Background: Diabetes mellitus (DM) induces oxidative stress and inflammation with negative effect on pregnancy outcomes. This study aimed to determine whether DM increases the risk of pregnancy loss and to identify other potential risk factors; (2) Methods: We identified female patients diagnosed with DM from 2000-2015 in the Taiwanese National Health Insurance Research Database according to the , Ninth Edition, Clinical Modification (ICD-9 CM) code 250. The event was pregnancy loss, defined as ICD-9 CM codes 630-639, which was tracked until 31 December 2015. The control group included 4-fold more non-DM female patients who were matched for age and disease severity. Multivariate Cox regression was employed to determine the risk factors associated with pregnancy loss; (3) Results: The hazard ratio (HR) for the risk of pregnancy loss due to DM was 1.407 (95% confidence interval: 1.099-1.801, = 0.007), and the risk factors for older age, gynecological disorders and inflammation disorders were included. (4) Conclusions: The study concluded that women with DM have a greater risk of experiencing pregnancy loss. Healthcare providers should proactively manage and educate diabetic patients to reduce their risk of pregnancy loss. Understanding other probable risk factors can help in developing targeted interventions and support systems for women to improve pregnancy outcomes.
（1）背景：糖尿病（DM）会引发氧化应激和炎症，对妊娠结局产生负面影响。本研究旨在确定糖尿病是否会增加流产风险，并识别其他潜在风险因素；（2）方法：我们根据《国际疾病分类第九版临床修订本》（ICD - 9 CM）编码250，从台湾国民健康保险研究数据库中识别出2000年至2015年期间被诊断为糖尿病的女性患者。事件为流产，定义为ICD - 9 CM编码630 - 639，追踪至2015年12月31日。对照组包括年龄和疾病严重程度相匹配的非糖尿病女性患者，数量为糖尿病患者的4倍。采用多变量Cox回归分析来确定与流产相关的风险因素；（3）结果：糖尿病导致流产风险的风险比（HR）为1.407（95%置信区间：1.099 - 1.801，P = 0.007），年龄较大、妇科疾病和炎症性疾病为风险因素。（4）结论：该研究得出结论，糖尿病女性发生流产的风险更高。医疗保健提供者应积极管理并教育糖尿病患者，以降低其流产风险。了解其他可能的风险因素有助于为女性制定有针对性的干预措施和支持系统，以改善妊娠结局。
