Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Napoli, Italy.
Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Napoli, Italy; Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche, Napoli, Italy.
Trends Mol Med. 2023 Sep;29(9):711-725. doi: 10.1016/j.molmed.2023.05.009. Epub 2023 Jun 16.
Embryo implantation failure and spontaneous abortions represent the main causes of infertility in developed countries. Unfortunately, incomplete knowledge of the multiple factors involved in implantation and fetal development keeps the success rate of medically assisted procreation techniques relatively low. According to recent literature, cellular and molecular mechanisms of 'immunogenic tolerance' towards the embryo are crucial to establish an 'anti-inflammatory' state permissive of a healthy pregnancy. In this review we dissect the role played by the immune system in the endometrial-embryo crosstalk, with a particular emphasis towards the fork-head-box-p3 (Foxp3) CD4CD25 regulatory T (Treg) cells and discuss the most recent therapeutic advances in the context of early immune-mediated pregnancy loss.
胚胎着床失败和自然流产是发达国家不孕的主要原因。不幸的是，由于对胚胎着床和胎儿发育过程中涉及的多种因素认识不足，使得辅助生殖技术的成功率相对较低。根据最近的文献，胚胎免疫原性耐受的细胞和分子机制对于建立允许健康妊娠的“抗炎”状态至关重要。在这篇综述中，我们剖析了免疫系统在子宫内膜-胚胎相互作用中的作用，特别强调了叉头框 P3（Foxp3）CD4CD25 调节性 T（Treg）细胞，并讨论了在早期免疫介导的妊娠丢失背景下最近的治疗进展。
