常染色体显性多囊肾病患者的自发性冠状动脉夹层：文献系统综述
Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature.
作者信息
Milutinovic Stefan, Bell Abraham, Jancic Predrag, Stanojevic Dragana, Borghol Abdul Hamid, Mina Jonathan, Chebib Fouad T, Khambati Ibrahim, Escarcega Ricardo O, Wood Malissa J
机构信息
Internal Medicine Residency Program at Lee Health, Florida State University College of Medicine, Cape Coral, FL 33909, USA.
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
出版信息
J Pers Med. 2024 Jun 29;14(7):702. doi: 10.3390/jpm14070702.
Spontaneous coronary artery dissection (SCAD) is a spontaneous intimal tear of the coronary artery wall. A factor rarely associated with SCAD is autosomal dominant polycystic kidney disease (ADPKD). Using the PRISMA guidelines, we identified 10 unique cases of SCAD in ADPKD patients reported between 1998 and 2021. Ages ranged from 36 to 59 years, with an average of 44.6 years. The majority of patients were female (80%). Each case was diagnosed with a cardiovascular event: ST-elevation myocardial infarction (STEMI) in 40%, non-ST elevation myocardial infarction (NSTEMI) in 50%, and stable angina in 10%. Conservative management was used in 60% of cases. There is a significant gap in our understanding of the relationship between SCAD and ADPKD. Polycystin complex can lead to structural abnormalities in blood vessels, resulting in vascular leaks and vessel rupture. This suggests that ADPKD patients may have an elevated risk of arteriopathies, including coronary artery dissection.
自发性冠状动脉夹层（SCAD）是一种冠状动脉壁的自发性内膜撕裂。常染色体显性多囊肾病（ADPKD）是一种很少与SCAD相关的因素。使用PRISMA指南，我们确定了1998年至2021年间报告的10例ADPKD患者中的SCAD独特病例。年龄范围为36至59岁，平均为44.6岁。大多数患者为女性（80%）。每个病例均被诊断为心血管事件：40%为ST段抬高型心肌梗死（STEMI），50%为非ST段抬高型心肌梗死（NSTEMI），10%为稳定型心绞痛。60%的病例采用保守治疗。我们对SCAD与ADPKD之间关系的理解存在显著差距。多囊蛋白复合物可导致血管结构异常，导致血管渗漏和血管破裂。这表明ADPKD患者可能有包括冠状动脉夹层在内的动脉病变风险升高。
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