• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

子宫间质肿瘤:病理学、分子图谱和治疗学的最新进展。

Uterine Mesenchymal Tumors: Updates on Pathology, Molecular Landscape, and Therapeutics.

机构信息

Pathology Department, King Fahd University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

出版信息

Medicina (Kaunas). 2024 Jul 2;60(7):1085. doi: 10.3390/medicina60071085.

DOI:10.3390/medicina60071085
PMID:39064514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278911/
Abstract

Mesenchymal uterine tumors are a diverse group of neoplasms with varying biological potential. Many of these neoplasms can have overlapping morphologic similarities, which, in some instances, render their diagnosis and categorization thorough histomorphologic examination inconclusive. In the last decade, an exponential amount of molecular data aiming to more accurately characterize and, consequently, treat these tumors have accumulated. The goal of this narrative review is to provide a pathologic review, a genetic update, and to know the new therapeutic avenues of primary uterine mesenchymal neoplasms.

摘要

间质子宫肿瘤是一组具有不同生物学潜能的多种肿瘤。其中许多肿瘤具有重叠的形态学相似性,在某些情况下,仅凭组织形态学检查无法明确诊断和分类。在过去十年中,积累了大量旨在更准确地描述这些肿瘤并因此进行治疗的分子数据。本文的目的是提供原发性子宫间质肿瘤的病理复习、遗传更新和新的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/4a2c86137d26/medicina-60-01085-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/38be94a52eed/medicina-60-01085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/c59df87849d2/medicina-60-01085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/795690f9242f/medicina-60-01085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/624df2fb591c/medicina-60-01085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/4a2c86137d26/medicina-60-01085-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/38be94a52eed/medicina-60-01085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/c59df87849d2/medicina-60-01085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/795690f9242f/medicina-60-01085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/624df2fb591c/medicina-60-01085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b9/11278911/4a2c86137d26/medicina-60-01085-g005.jpg

相似文献

1
Uterine Mesenchymal Tumors: Updates on Pathology, Molecular Landscape, and Therapeutics.子宫间质肿瘤:病理学、分子图谱和治疗学的最新进展。
Medicina (Kaunas). 2024 Jul 2;60(7):1085. doi: 10.3390/medicina60071085.
2
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.子宫平滑肌以外的其他间叶性肿瘤
Surg Pathol Clin. 2019 Mar;12(1):107-137. doi: 10.1016/j.path.2018.10.005. Epub 2018 Dec 24.
3
Pure mesenchymal neoplasms of the uterine corpus: selected problems.子宫体部的纯间质性肿瘤:若干选定问题
Semin Diagn Pathol. 1988 May;5(2):172-98.
4
Update on Uterine Mesenchymal Neoplasms.子宫间质肿瘤的最新进展。
Surg Pathol Clin. 2022 Jun;15(2):315-340. doi: 10.1016/j.path.2022.02.008. Epub 2022 May 20.
5
Uterine Mesenchymal Tumors: Update on Classification, Staging, and Molecular Features.子宫间叶肿瘤:分类、分期及分子特征的最新进展
Surg Pathol Clin. 2019 Jun;12(2):363-396. doi: 10.1016/j.path.2019.01.004.
6
Uterine Mesenchymal Tumors: Hereditary Aspects.子宫间质肿瘤:遗传方面。
Adv Anat Pathol. 2018 Mar;25(2):96-105. doi: 10.1097/PAP.0000000000000175.
7
Hyperhaploid uterine mesenchymal tumors-a novel genetic subgroup?超单倍体子宫间叶肿瘤——一个新的基因亚组?
Cancer Genet. 2016 Jun;209(6):278-81. doi: 10.1016/j.cancergen.2016.02.005. Epub 2016 Mar 8.
8
Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.复发性 KAT6B/A::KANSL1 融合型肿瘤具有侵袭性,其组织形态学上与低级别子宫内膜间质肉瘤重叠。
Am J Surg Pathol. 2022 Sep 1;46(9):1298-1308. doi: 10.1097/PAS.0000000000001915. Epub 2022 May 17.
9
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.子宫肉瘤和罕见的具有恶性潜能的子宫间叶性肿瘤。法国肉瘤集团和罕见妇科肿瘤集团的诊断指南。
Gynecol Oncol. 2022 Nov;167(2):373-389. doi: 10.1016/j.ygyno.2022.07.031. Epub 2022 Sep 14.
10
Uterine inflammatory myofibroblastic tumors in pregnant women with and without involvement of the placenta: a study of 6 cases with identification of a novel TIMP3-RET fusion.孕妇合并和不合并胎盘累及的子宫炎性肌纤维母细胞瘤:6 例研究并鉴定出一种新型 TIMP3-RET 融合基因。
Hum Pathol. 2020 Mar;97:29-39. doi: 10.1016/j.humpath.2019.12.006. Epub 2020 Jan 7.

引用本文的文献

1
Demographic and Clinicopathological Analysis of Leiomyosarcoma at Various Anatomical Sites: A Tertiary Care Hospital Experience.不同解剖部位平滑肌肉瘤的人口统计学和临床病理分析:一家三级医疗中心的经验
Cureus. 2025 May 31;17(5):e85124. doi: 10.7759/cureus.85124. eCollection 2025 May.
2
Molecular Insights in Endometrial Stromal Sarcomas: Exploring New Targets for Novel Therapeutic Approaches.子宫内膜间质肉瘤的分子见解:探索新型治疗方法的新靶点
Biomolecules. 2025 Feb 11;15(2):265. doi: 10.3390/biom15020265.
3
A Primary Low-Grade Vaginal Extrauterine Endometrial Stromal Sarcoma: A Case Report.

本文引用的文献

1
Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).奥拉帕利和替莫唑胺治疗晚期子宫平滑肌肉瘤的 II 期研究(NCI 方案 10250)。
J Clin Oncol. 2023 Sep 1;41(25):4154-4163. doi: 10.1200/JCO.23.00402. Epub 2023 Jul 19.
2
Analysis of histology-agnostic targets among soft tissue and bone sarcomas in the AACR GENIE database.AACR GENIE数据库中软组织和骨肉瘤的组织学无关靶点分析。
Front Oncol. 2023 Jan 18;12:1079909. doi: 10.3389/fonc.2022.1079909. eCollection 2022.
3
Uterine Sarcoma With FGFR1-TACC1 Gene Fusion: A Case Report and Review of the Literature.
原发性低级别阴道外子宫内膜间质肉瘤:一例报告
Reprod Sci. 2025 May;32(5):1699-1704. doi: 10.1007/s43032-025-01810-0. Epub 2025 Feb 18.
4
A Simple Eco-Friendly HPLC-PDA Method for the Simultaneous Determination of Paclitaxel and Seliciclib in Plasma Samples for Assessing Their Pharmacodynamics and Pharmacokinetics in Combination Therapy for Uterine Sarcoma.一种简单的环保型 HPLC-PDA 方法,用于同时测定血浆样品中的紫杉醇和塞利昔布,以评估它们在联合治疗子宫肉瘤中的药效学和药代动力学。
Medicina (Kaunas). 2024 Sep 29;60(10):1601. doi: 10.3390/medicina60101601.
子宫肉瘤伴 FGFR1-TACC1 基因融合:病例报告及文献复习。
Int J Gynecol Pathol. 2022 Nov 1;41(6):588-592. doi: 10.1097/PGP.0000000000000846. Epub 2021 Dec 1.
4
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.子宫肉瘤和罕见的具有恶性潜能的子宫间叶性肿瘤。法国肉瘤集团和罕见妇科肿瘤集团的诊断指南。
Gynecol Oncol. 2022 Nov;167(2):373-389. doi: 10.1016/j.ygyno.2022.07.031. Epub 2022 Sep 14.
5
Novel Therapeutics in the Treatment of Uterine Sarcoma.新型疗法治疗子宫肉瘤。
Am Soc Clin Oncol Educ Book. 2022 Apr;42:900-909. doi: 10.1200/EDBK_350541.
6
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.特定谱系的平滑肌肉瘤亚型在诊断前多年出现,并决定患者的生存。
Nat Commun. 2021 Jul 23;12(1):4496. doi: 10.1038/s41467-021-24677-6.
7
YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways.YWHAE-NUTM2癌蛋白通过RAF/MAPK和Hippo信号通路调控细胞增殖和细胞周期蛋白D1 。
Oncogenesis. 2021 May 4;10(5):37. doi: 10.1038/s41389-021-00327-w.
8
Neurofibrosarcoma Revisited: An Institutional Case Series of Uterine Sarcomas Harboring Kinase-related Fusions With Report of a Novel FGFR1-TACC1 Fusion.神经纤维肉瘤再探:具有激酶相关融合的子宫肉瘤的机构病例系列,报道一种新型 FGFR1-TACC1 融合。
Am J Surg Pathol. 2021 May 1;45(5):638-652. doi: 10.1097/PAS.0000000000001644.
9
COL1A1-PDGFB fusion uterine sarcoma and its response to Imatinib therapy.COL1A1-PDGFB融合性子宫肉瘤及其对伊马替尼治疗的反应。
Gynecol Oncol Rep. 2020 Sep 25;34:100653. doi: 10.1016/j.gore.2020.100653. eCollection 2020 Nov.
10
Recent advances in smooth muscle tumors with PGR and PLAG1 gene fusions and myofibroblastic uterine neoplasms.PGR 和 PLAG1 基因融合的平滑肌肿瘤及肌纤维母细胞性子宫肿瘤的最新进展。
Genes Chromosomes Cancer. 2021 Mar;60(3):138-146. doi: 10.1002/gcc.22920. Epub 2020 Dec 8.