Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Department of Nursing and Midwifery, Rīga Stradiņš University, LV-1007 Riga, Latvia.
Medicina (Kaunas). 2024 Jul 3;60(7):1089. doi: 10.3390/medicina60071089.
: Radiofrequency catheter ablation (RFCA) is a highly successful intervention. By comparing the lesion changes in prostate parenchymal and striated muscle tissues after RFCA with and without cooling, it was possible to assess the correlation between the shape regularity, area, and perimeter of the thermal lesion, and to predict the geometric shape changes of the lesions. : A standard prostate and striated muscle RFCA procedure was performed on 13 non-purebred dogs in two sessions: no cooling and cooling with 0.1% NaCl solution. Microtome-cut 2-3 µm sections of tissue samples were stained with haematoxylin and eosin and further examined. The quotient formula was employed to evaluate the geometric shape of the damage zones at the ablation site. : The extent of injury following RFCA in striated muscle tissue was comparable to that in prostate parenchymal tissue. Regression analysis indicated a strong and positive relationship between area and perimeter in all experimental groups. In the experimental groups of parenchymal tissues with and without cooling, an increase in the area or perimeter of the damage zone corresponded to an increase in the quotient value. A similar tendency was observed in the striated muscle group with cooling. However, in the striated muscle group without cooling, an increase in lesion area or perimeter lowered the quotient value. Standardised regression coefficients demonstrated that in the striated muscle with cooling, the damage zone shape was more determined by area than perimeter. However, in the parenchymal tissue, the perimeter had a more substantial impact on the damage zone shape than the area. : The damage area and perimeter have predictive power on the overall shape regularity of damage zone geometry in both striated muscles and parenchymal tissue. This approach is employed to achieve a balance between the need for tumour eradication and the minimisation of ablation-induced complications to healthy tissue.
射频导管消融 (RFCA) 是一种非常成功的介入治疗方法。通过比较 RFCA 后前列腺实质和横纹肌组织的病变变化，有无冷却，可以评估热损伤的形状规则性、面积和周长之间的相关性，并预测病变的几何形状变化。
在两个疗程中，对 13 只非纯种犬进行了标准的前列腺和横纹肌 RFCA 手术：无冷却和 0.1%NaCl 溶液冷却。使用组织学切片机切割 2-3µm 的组织样本，用苏木精和伊红染色，然后进一步检查。使用商公式评估消融部位损伤区域的几何形状。
横纹肌组织中 RFCA 后的损伤程度与前列腺实质组织相当。回归分析表明，在所有实验组中，面积和周长之间存在强烈的正相关关系。在有冷却和无冷却的实质组织实验组中，损伤区域的面积或周长增加对应着商值的增加。在有冷却的横纹肌组中观察到类似的趋势。然而，在无冷却的横纹肌组中，病变面积或周长的增加会降低商值。标准化回归系数表明，在有冷却的横纹肌中，损伤区域的形状更多地由面积决定，而不是周长。然而，在实质组织中，周长对损伤区域形状的影响比面积更大。
损伤面积和周长对横纹肌和实质组织损伤区域整体形状规则性具有预测能力。这种方法用于在肿瘤根除的需求和对健康组织的消融诱导并发症的最小化之间取得平衡。
