Department of Internal Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Burroughs Wellcome Fund Fellow, Texas A&M Academy of Physician Scientists, Houston TX 77030, USA.
Medicina (Kaunas). 2024 Jul 16;60(7):1146. doi: 10.3390/medicina60071146.
Esophageal cancer (EC) comprises 1% of all diagnosed cancers in the USA. It is more common in other parts of the world. If there is distant metastasis, the relative survival rate is 6%. There are no standardized screening methods for EC. We reported a four-year case of esophageal cancer, a P53-positive mutation with atypical distant metastasis to the cardiac and skeletal muscles. The patient was managed with multimodal therapy, including immunotherapy, which could have been a factor in prolonged survival. Distant metastases are typically seen postmortem, and with prolonged survival, we are able to find such unique metastases antemortem. Despite a history of negative scans, the patient's ctDNA (circulating tumor DNA) remained positive, which was a better predictor of recurrence in this case. Future research is required to establish cost-effective screening methods and standardized treatments.
食管癌（EC）在美国所有诊断出的癌症中占 1%。在世界其他地区更为常见。如果发生远处转移，相对生存率为 6%。目前尚无针对食管癌的标准化筛查方法。我们报告了一例食管癌病例，该病例 P53 阳性突变，表现为心脏和骨骼肌的非典型远处转移。患者接受了包括免疫疗法在内的多模式治疗，这可能是延长生存的一个因素。远处转移通常在死后发现，随着生存时间的延长，我们能够在生前发现这种独特的转移。尽管有阴性扫描的病史，但患者的 ctDNA（循环肿瘤 DNA）仍然呈阳性，这在这种情况下是复发的更好预测指标。需要进一步的研究来建立具有成本效益的筛查方法和标准化治疗。
