Li Wanneng, Zhan Minle, Wen Yue, Chen Yu, Zhang Zhongchao, Wang Shuhui, Tian Dean, Tian Sidan
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Pharmaceutics. 2024 Jul 10;16(7):921. doi: 10.3390/pharmaceutics16070921.
The gut microbiota is closely associated with human health, and alterations in gut microbiota can influence various physiological and pathological activities in the human body. Therefore, microbiota regulation has become an important strategy in current disease treatment, albeit facing numerous challenges. Nanomaterials, owing to their excellent protective properties, drug release capabilities, targeting abilities, and good biocompatibility, have been widely developed and utilized in pharmaceuticals and dietary fields. In recent years, significant progress has been made in research on utilizing nanomaterials to assist in regulating gut microbiota for disease intervention. This review explores the latest advancements in the application of nanomaterials for microbiota regulation and offers insights into the future development of nanomaterials in modulating gut microbiota.
肠道微生物群与人类健康密切相关,肠道微生物群的改变会影响人体的各种生理和病理活动。因此,微生物群调节已成为当前疾病治疗的重要策略,尽管面临诸多挑战。纳米材料因其优异的保护性能、药物释放能力、靶向能力和良好的生物相容性,已在制药和饮食领域得到广泛开发和应用。近年来,在利用纳米材料辅助调节肠道微生物群以进行疾病干预的研究方面取得了重大进展。本文综述探讨了纳米材料在微生物群调节应用中的最新进展,并对纳米材料在调节肠道微生物群方面的未来发展提供了见解。