Zhang Yi, Zhao Xiaotong, Zhang Jingxian, Zhang Yaodong, Wei Yongjun
Henan Key Laboratory of Children's Genetics and Metabolic Diseases, School of Pharmaceutical Sciences, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou University, Zhengzhou, China.
Front Microbiol. 2024 Jul 3;15:1423838. doi: 10.3389/fmicb.2024.1423838. eCollection 2024.
The human gut microbiota is a complex ecosystem that plays a crucial role in promoting the interaction between the body and its environment. It has been increasingly recognized that the gut microbiota has diverse physiological functions. Recent studies have shown a close association between the gut microbiota and the development of certain tumors, including leukemia. Leukemia is a malignant clonal disease characterized by the uncontrolled growth of one or more types of blood cells, which is the most common cancer in children. The imbalance of gut microbiota is linked to the pathological mechanisms of leukemia. Probiotics, which are beneficial microorganisms that help maintain the balance of the host microbiome, play a role in regulating gut microbiota. Probiotics have the potential to assist in the treatment of leukemia and improve the clinical prognosis of leukemia patients. This study reviews the relationship between gut microbiota, probiotics, and the progression of leukemia based on current research. In addition, utilizing zebrafish leukemia models in future studies might reveal the specific mechanisms of their interactions, thereby providing new insights into the clinical treatment of leukemia. In conclusion, further investigation is still needed to fully understand the accurate role of microbes in leukemia.
人类肠道微生物群是一个复杂的生态系统，在促进身体与其环境之间的相互作用中起着关键作用。人们越来越认识到肠道微生物群具有多种生理功能。最近的研究表明，肠道微生物群与某些肿瘤（包括白血病）的发生发展密切相关。白血病是一种恶性克隆性疾病，其特征是一种或多种血细胞不受控制地生长，是儿童中最常见的癌症。肠道微生物群的失衡与白血病的病理机制有关。益生菌是有助于维持宿主微生物群平衡的有益微生物，在调节肠道微生物群方面发挥作用。益生菌有可能辅助白血病的治疗并改善白血病患者的临床预后。本研究基于当前研究综述了肠道微生物群、益生菌与白血病进展之间的关系。此外，在未来的研究中利用斑马鱼白血病模型可能会揭示它们相互作用的具体机制，从而为白血病的临床治疗提供新的见解。总之，仍需要进一步研究以充分了解微生物在白血病中的确切作用。
