Zhang Hairui, Yao Jiali, Jiang Qianyang, Shi Yurou, Ge Weihong, Xu Xiaoling
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China.
Pharmaceutics. 2024 Jul 13;16(7):935. doi: 10.3390/pharmaceutics16070935.
Androgenetic alopecia (AGA) is a highly prevalent condition in contemporary society. The conventional treatment of minoxidil tincture is hindered by issues such as skin irritation caused by ethanol, non-specific accumulation in hair follicles, and short retention due to its liquid form. Herein, we have developed a novel minoxidil-incorporated engineered exosomes biopotentiated hydrogel (Gel@MNs) that has the capability to modulate the perifollicular microenvironment for the treatment of AGA. Leveraging the exceptional skin penetration abilities of flexible liposomes and the targeting properties of exosomes, the encapsulated minoxidil can be effectively delivered to the hair follicles. In comparison to free minoxidil, Gel@MNs demonstrated accelerated hair regeneration in an AGA mouse model without causing significant skin irritation. This was evidenced by an increase in both the number and size of hair follicles within the dermal layer, enhanced capillary formation surrounding the follicles, and the regulation of the transition of hair follicle cells from the telogen phase to the anagen growth phase. Therefore, this safe and microenvironment-modifying hybrid exosome-embedded hydrogel shows promising potential for clinical treatment of AGA.
雄激素性脱发（AGA）在当代社会是一种高度普遍的病症。传统的米诺地尔酊剂治疗受到诸如乙醇引起的皮肤刺激、在毛囊中的非特异性积累以及因其液体形式导致的短保留时间等问题的阻碍。在此，我们开发了一种新型的载有米诺地尔的工程化外泌体生物增强水凝胶（Gel@MNs），其具有调节毛囊周围微环境以治疗AGA的能力。利用柔性脂质体出色的皮肤穿透能力和外泌体的靶向特性，包封的米诺地尔能够有效地递送至毛囊。与游离米诺地尔相比，Gel@MNs在AGA小鼠模型中显示出加速的毛发生长，且未引起明显的皮肤刺激。这通过真皮层内毛囊数量和大小的增加、毛囊周围毛细血管形成的增强以及毛囊细胞从休止期向生长期转变的调节得到证明。因此，这种安全且能改变微环境的嵌入外泌体的混合水凝胶在AGA的临床治疗中显示出有前景的潜力。
