Lucinian Yousif A, Martineau Patrick, Abikhzer Gad, Harel Francois, Pelletier-Galarneau Matthieu
Montreal Heart Institute, Montreal, Quebec, Canada.
BC Cancer, Vancouver, British Columbia, Canada.
J Nucl Cardiol. 2024 Dec;42:102012. doi: 10.1016/j.nuclcard.2024.102012. Epub 2024 Jul 26.
Myocardial inflammation plays a central role in the pathophysiology of various cardiac diseases. While FDG-PET is currently the primary method for molecular imaging of myocardial inflammation, its effectiveness is hindered by physiological myocardial uptake as well as its propensity for uptake by multiple disease-specific mechanisms. Novel radiotracers targeting diverse inflammatory immune cells and molecular pathways may provide unique insight through the visualization of underlying mechanisms central to the pathogenesis of inflammatory cardiac diseases, offering opportunities for increased understanding of immunocardiology. Moreover, the potentially enhanced specificity may lead to better quantification of disease activity, aiding in the guidance and monitoring of immunomodulatory therapy. This review aims to provide an update on advancements in non-FDG radiotracers for imaging myocardial inflammatory diseases, with a focus on cardiac sarcoidosis, myocarditis, and acute myocardial infarction.
心肌炎症在各种心脏疾病的病理生理学中起着核心作用。虽然氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）目前是心肌炎症分子成像的主要方法，但其有效性受到生理性心肌摄取以及多种疾病特异性摄取机制的影响。针对不同炎症免疫细胞和分子途径的新型放射性示踪剂，可能通过可视化炎症性心脏病发病机制的核心潜在机制，提供独特的见解，为增进对免疫心脏病学的理解提供机会。此外，潜在增强的特异性可能导致对疾病活动的更好量化，有助于指导和监测免疫调节治疗。本综述旨在提供关于用于成像心肌炎症性疾病的非FDG放射性示踪剂进展的最新情况，重点关注心脏结节病、心肌炎和急性心肌梗死。
