用于心肌炎症分子成像的新型放射性示踪剂：聚焦于非18F-FDG放射性示踪剂临床转化的最新进展
Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers.
作者信息
Shi Tiantian, Miller Edward J
机构信息
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT USA.
出版信息
Curr Cardiovasc Imaging Rep. 2023;16(1):1-9. doi: 10.1007/s12410-023-09574-4. Epub 2023 Mar 9.
PURPOSE OF REVIEW
The purpose of this paper is to provide a focused update on recent advances in non-18F-FDG radiotracers for myocardial inflammatory diseases, with a focus on cardiac sarcoidosis and myocarditis.
RECENT FINDINGS
Novel radiotracers targeting molecular features of inflammation have the potential to visualize underlying molecular mechanisms key to the pathogenesis of inflammatory cardiomyopathies such as sarcoidosis and myocarditis. These radiotracers may provide unique opportunities for improved mechanistic insight, higher specificity, and better quantification of disease activity, as well as potential for guidance and monitoring of immunomodulatory therapies.
SUMMARY
Novel radiotracers provide unique possibilities in diagnosis, prognostic performance, and therapy guidance for cardiac sarcoidosis and myocarditis.
综述目的
本文旨在重点介绍用于心肌炎性疾病的非18F-FDG放射性示踪剂的最新进展，重点关注心脏结节病和心肌炎。
最新发现
针对炎症分子特征的新型放射性示踪剂有可能可视化炎症性心肌病（如结节病和心肌炎）发病机制的关键潜在分子机制。这些放射性示踪剂可能为深入了解机制、提高特异性、更好地量化疾病活动提供独特机会，以及为免疫调节治疗提供指导和监测的潜力。
总结
新型放射性示踪剂在心脏结节病和心肌炎的诊断、预后评估及治疗指导方面提供了独特的可能性。
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