Yang Xiaoyan, Zhou Bing
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China.
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China; School of Engineering Medicine, Beihang University, Beijing 100191, China.
Trends Endocrinol Metab. 2025 Feb;36(2):161-175. doi: 10.1016/j.tem.2024.07.001. Epub 2024 Jul 27.
Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration. However, the exact contribution of cellular metabolism to this process remains elusive. Insights into the metabolic characteristics of proliferative cells may illuminate similar mechanisms operating in axon regeneration; therefore, unraveling previously unappreciated roles of metabolic adaptation is critical to achieving neuron regrowth, which is connected to the therapeutic strategies for neurological conditions necessitating nerve repairs, such as spinal cord injury and stroke. Here, we outline the metabolic role in axon regeneration and discuss factors enhancing nerve regrowth, highlighting potential novel metabolic treatments for restoring nerve function.
轴突再生需要动员细胞内资源，包括蛋白质、脂质和核苷酸。损伤后，神经元需要调整其新陈代谢，以满足轴突再生所需的生物合成需求。然而，细胞代谢对这一过程的确切贡献仍不清楚。深入了解增殖细胞的代谢特征可能会揭示轴突再生中类似的作用机制；因此，揭示代谢适应先前未被认识的作用对于实现神经元再生至关重要，这与脊髓损伤和中风等需要神经修复的神经疾病的治疗策略相关。在这里，我们概述了代谢在轴突再生中的作用，并讨论了促进神经再生的因素，强调了恢复神经功能的潜在新型代谢治疗方法。
