Internal Medicine Department, University Hospital Complex of Badajoz, Avda de Elvas, S/N. 06085, Badajoz, Spain.
Internal Medicine Department, University Hospital Complex of Badajoz, Avda de Elvas, S/N. 06085, Badajoz, Spain.
Nutr Metab Cardiovasc Dis. 2024 Nov;34(11):2511-2518. doi: 10.1016/j.numecd.2024.06.016. Epub 2024 Jun 24.
Obesity is characterized by alterations in fat and muscle mass. Phase angle (PhA) is considered an index of muscle mass, and is related to comorbidities in SO. This work aimed to assess the relationship between PhA, muscle mass, inflammation, and comorbidities in obesity.
We included 198 outpatients with obesity (BMI≥30) divided into tertiles according to PhA distribution (<5°, 5°-6°, >7°). Body composition was analyzed using bioimpedance (Tanita MC-780P Multi-Frequency Segmental Body Composition Analyzer). Quantitative variables were compared using the Kruskal-Wallis test and qualitative variables using the chi-square test. A correspondence analysis was built to show the influence of qualitative variables on subjects in each tertile. Patients in the lowest tertile had the lowest skeletal muscle mass and appendicular skeletal muscle mass index (ASMI); the highest inflammatory index (albumin and derived neutrophil-to-lymphocyte ratio, Alb-dNLR); and the highest percentage of individuals with a history of type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and heart failure (HF). The correspondence analysis showed an association between the lowest tertile and presence of HF with preserved ejection fraction (HFpEF) and CKD. On the logistic regression model, ASMI (OR 0.9, 95%CI 0.85-0.95, p = 0.0004), Alb-dNLR (OR 1.04, 95%CI 1.04-16.4, p = 0.04) and HFpEF and T2DM were significantly associated with the lowest PhA.
Identifying high-risk individuals living with obesity is a priority. These results show that lower PhA is related to inflammation, poorer skeletal muscle mass and consequently, their impact on obesity-related comorbidities and clinical outcomes.
肥胖的特征是脂肪和肌肉量的改变。相位角（PhA）被认为是肌肉量的指标，与 SO 的合并症有关。本研究旨在评估肥胖患者中 PhA、肌肉量、炎症和合并症之间的关系。
我们纳入了 198 名肥胖门诊患者（BMI≥30），根据 PhA 分布（<5°、5°-6°、>7°）分为三组。使用生物阻抗法（Tanita MC-780P 多频分段身体成分分析仪）分析身体成分。使用 Kruskal-Wallis 检验比较定量变量，使用卡方检验比较定性变量。构建对应分析以显示定性变量对每组中受试者的影响。最低 tertile 组的骨骼肌质量和四肢骨骼肌质量指数（ASMI）最低；炎症指数（白蛋白和衍生的中性粒细胞与淋巴细胞比值，Alb-dNLR）最高；患有 2 型糖尿病（T2DM）、慢性肾脏病（CKD）和心力衰竭（HF）病史的个体比例最高。对应分析显示最低 tertile 与射血分数保留性心力衰竭（HFpEF）和 CKD 的存在之间存在关联。在逻辑回归模型中，ASMI（OR 0.9，95%CI 0.85-0.95，p=0.0004）、Alb-dNLR（OR 1.04，95%CI 1.04-16.4，p=0.04）和 HFpEF 和 T2DM 与最低 PhA 显著相关。
确定患有肥胖症的高危个体是当务之急。这些结果表明，较低的 PhA 与炎症、较差的骨骼肌质量有关，进而影响肥胖相关的合并症和临床结局。
