日本发生全氟辛烷磺酸免疫毒性的风险低吗？：日本受污染地区的人体生物监测研究。
Is Japan at low risk for PFAS immunotoxicity?: human biomonitoring study in contaminated areas in Japan.
机构信息
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine.
NPO Japan Endocrine-disruptor Preventive Action.
出版信息
Environ Health Prev Med. 2024;29:37. doi: 10.1265/ehpm.24-00047.
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) are now considered global contaminants posing health risks. Recent human biomonitoring data in Japan are presented.
METHODS
Human biomonitoring data from Japan, dating back to 2000, were reviewed. In addition, 399 serum samples collected in a primary care clinic in Urayasu City, Okinawa Island-one of the highest PFAS-exposed areas in Japan-between 2021 and 2022 were analyzed. Serum levels of four PFAS were compared with risk levels based on the assessment by Sonne et al. and the European Food Safety Agency.
RESULTS
The PFAS levels in the general population from various areas other than Hokkaido (16.1-43.5 ng/mL) are classified at moderate to severe risk for immunotoxicity based on the assessment.
CONCLUSIONS
A portion of the Japanese population has had high exposure to PFAS and was at high risk of immunotoxicity, and this situation remained in PFAS-contaminated areas in the 2020s.
背景
全氟和多氟烷基物质（PFAS）现已被认为是对健康构成威胁的全球性污染物。本文呈现了日本最近的人体生物监测数据。
方法
回顾了日本自 2000 年以来的人体生物监测数据。此外，还对 2021 年至 2022 年在冲绳岛浦添市的一家初级保健诊所采集的 399 份血清样本进行了分析，该地区是日本 PFAS 暴露水平最高的地区之一。根据 Sonne 等人的评估和欧洲食品安全局的评估，比较了四种 PFAS 的血清水平与风险水平。
结果
除北海道以外的其他地区（16.1-43.5ng/mL）的一般人群的 PFAS 水平被归类为中度至严重的免疫毒性风险。
结论
一部分日本人接触 PFAS 的程度较高，免疫毒性风险较高，这种情况在 21 世纪 20 年代仍存在于 PFAS 污染地区。
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