Changes in surface topography of Candida albicans during morphogenesis.

Temporal studies of germ-tube forming yeast cells of Candida albicans by scanning and transmission electron microscopy indicate that extensive vacuolation and possibly also cell wall changes may cause walls of the parent yeast cell to collapse during specimen preparation. This collapse does not occur in cells which have been grown in conditions that suppress germ tube formation and have undergone the same preparative treatment.