Lee Hye-Jin, Park Young-Min, Shim Miseon
Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Department of Artificial Intelligence, Tech University of Korea, Siheung, Korea.
Clin Psychopharmacol Neurosci. 2024 Aug 31;22(3):451-457. doi: 10.9758/cpn.23.1133. Epub 2023 Dec 6.
: Nonsuicidal self-injury (NSSI), which involves deliberate harm to body tissues without suicidal intent, represents an escalating clinical concern. We used electroencephalography (EEG) to investigate the differences in functional connectivity (FC) patterns in patients with depression with and without a history of NSSI.
: Seventy-seven patients with mood disorders experiencing major depressive episodes were categorized into NSSI (Group A; n = 31) and non-NSSI (Group B; n = 46) groups on the basis of their NSSI history. EEG data were collected and FC was analyzed using coherence (Coh), imaginary coherence (iCoh), and phase-locking value (PLV) metrics. Network indices based on graph theory were calculated. Demographic and clinical characteristics and scale scores were compared between groups A and B.
: While the two groups showed no significant differences in demographic characteristics such as age and diagnosis, the Beck Depression Inventory and Suicidal Ideation Questionnaire (SIQ) scores were higher in Group A. Binary logistic regression analyses revealed associations of NSSI with sex and the SIQ score. We examined the connectivity of 1,326 pairs of signals across six frequency bands, yielding 7,956 signal pairs. The two groups showed no significant differences in the Coh, iCoh, corrected PLV, or network indices but showed significant differences in all the frequency bands when an uncorrected test was used.
: In this study, FC differences in depression with and without NSSI were not observed. Further well-controlled research is expected to clarify neurobiological underpinnings and guide future interventions.
非自杀性自伤（NSSI）是指故意对身体组织造成伤害但无自杀意图，这一现象在临床上日益受到关注。我们使用脑电图（EEG）来研究有和没有NSSI病史的抑郁症患者在功能连接（FC）模式上的差异。
77例经历重度抑郁发作的情绪障碍患者根据其NSSI病史被分为NSSI组（A组；n = 31）和非NSSI组（B组；n = 46）。收集EEG数据，并使用相干性（Coh）、虚相干性（iCoh）和锁相值（PLV）指标分析FC。计算基于图论的网络指数。比较A组和B组的人口统计学和临床特征以及量表得分。
虽然两组在年龄和诊断等人口统计学特征上没有显著差异，但A组的贝克抑郁量表和自杀意念问卷（SIQ）得分更高。二元逻辑回归分析显示NSSI与性别和SIQ得分有关。我们检查了六个频段上1326对信号的连接性，得到7956个信号对。两组在Coh、iCoh、校正后的PLV或网络指数上没有显著差异，但在使用未校正检验时，在所有频段上均显示出显著差异。
在本研究中，未观察到有和没有NSSI的抑郁症患者在FC上的差异。期待进一步严格控制的研究来阐明神经生物学基础并指导未来的干预措施。
