Burke Benjamin I, Ismaeel Ahmed, von Walden Ferdinand, Murach Kevin A, McCarthy John J
Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.
Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.
Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C614-C618. doi: 10.1152/ajpcell.00418.2024. Epub 2024 Jul 29.
Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that "cell growth is cell growth" and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth.
罗伯茨等人针对我们关于协同肌消融模型效用的综述文章提出了深刻的反驳观点。本综述的目的是就协同肌消融模型的优缺点展开进一步讨论。具体而言，我们强调该模型的稳健性掩盖了手术局限性。我们还比较了小鼠协同肌消融与人类抗阻运动后的转录组反应，以确定共同途径。我们得出结论：“细胞生长就是细胞生长”，细胞积累生物量并增大尺寸的机制在不同细胞类型中相似，且与生长速率无关。
