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本文引用的文献

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Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.肌肉来源的小细胞外囊泡在过度训练期间会诱发肝纤维化。
Cell Metab. 2025 Apr 1;37(4):824-841.e8. doi: 10.1016/j.cmet.2024.12.005. Epub 2025 Jan 28.
2
Physiology and Pathophysiology of Marathon Running: A narrative Review.马拉松跑的生理学与病理生理学：一篇叙述性综述
Sports Med Open. 2025 Jan 27;11(1):10. doi: 10.1186/s40798-025-00810-3.
3
Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.细胞外囊泡介导的 miR-1 向脂肪组织的转移可改变抗阻运动后的脂肪分解途径。
JCI Insight. 2024 Nov 8;9(21):e182589. doi: 10.1172/jci.insight.182589.
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Skeletal muscle hypertrophy: cell growth is cell growth.骨骼肌肥大：细胞生长就是细胞生长。
Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C614-C618. doi: 10.1152/ajpcell.00418.2024. Epub 2024 Jul 29.
5
The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy.啮齿动物协同消融模型在鉴定骨骼肌肥大的分子和细胞机制中的效用。
Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C601-C606. doi: 10.1152/ajpcell.00362.2024. Epub 2024 Jul 29.
6
Acute Resistance Exercise Modifies Extracellular Vesicle miRNAs Targeting Anabolic Gene Pathways: A Prospective Cohort Study.急性抗阻运动改变细胞外囊泡 miRNA 靶向合成代谢基因通路：一项前瞻性队列研究。
Med Sci Sports Exerc. 2024 Jul 1;56(7):1225-1232. doi: 10.1249/MSS.0000000000003408. Epub 2024 Feb 9.
7
Skeletal muscle-derived extracellular vesicles transport glycolytic enzymes to mediate muscle-to-bone crosstalk.骨骼肌来源的细胞外囊泡转运糖酵解酶介导肌肉与骨骼间的串扰。
Cell Metab. 2023 Nov 7;35(11):2028-2043.e7. doi: 10.1016/j.cmet.2023.10.013.
8
Exercise Improves Metabolism and Alleviates Atherosclerosis via Muscle-Derived Extracellular Vesicles.运动通过肌肉衍生的细胞外囊泡改善新陈代谢并减轻动脉粥样硬化。
Aging Dis. 2023 Jun 1;14(3):952-965. doi: 10.14336/AD.2022.1131.
9
Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise.单细胞分析显示，高强度间歇性运动导致四跨膜蛋白阳性细胞外囊泡大量释放到循环中。
J Physiol. 2023 Nov;601(22):5093-5106. doi: 10.1113/JP284047. Epub 2023 Mar 16.
10
A brief history of nearly EV-erything - The rise and rise of extracellular vesicles.几乎万物简史——细胞外囊泡的兴起与发展。
J Extracell Vesicles. 2021 Dec;10(14):e12144. doi: 10.1002/jev2.12144.

从获益到肝痛：运动训练过度时的情况。

From gains to liver pain: when exercise training goes too far.

作者信息

Burke Benjamin I, McCarthy John J, Ismaeel Ahmed

机构信息

Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40506, USA.

Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY 40506, USA.

出版信息

Extracell Vesicles Circ Nucl Acids. 2025 Jun 25;6(2):324-327. doi: 10.20517/evcna.2025.36. eCollection 2025.

DOI:10.20517/evcna.2025.36
PMID:40852599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12367453/
Abstract

A recent study from Liu described the role of skeletal muscle-derived extracellular vesicles in promoting liver fibrosis as an outcome of chronic overtraining in mice. Here, we highlight this work and discuss its implications within the fields of exercise physiology and inter-organ communication.

摘要

刘最近的一项研究描述了骨骼肌衍生的细胞外囊泡在促进肝纤维化中的作用，这是小鼠慢性过度训练的一个结果。在此，我们重点介绍这项工作，并讨论其在运动生理学和器官间通讯领域的意义。