• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Correlation of insertion/deletion gene polymorphism with captopril effectiveness in Indonesian hypertensive patients.插入/缺失基因多态性与卡托普利在印度尼西亚高血压患者中的疗效相关性。
Pharmacogenomics. 2024;25(8-9):357-365. doi: 10.1080/14622416.2024.2375190. Epub 2024 Jul 29.
2
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease.血管紧张素转换酶（ACE）抑制剂用于镰状细胞病患者的蛋白尿和微量白蛋白尿。
Cochrane Database Syst Rev. 2015 Jun 4;2015(6):CD009191. doi: 10.1002/14651858.CD009191.pub3.
3
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease.血管紧张素转换酶（ACE）抑制剂用于镰状细胞病患者的蛋白尿和微量白蛋白尿。
Cochrane Database Syst Rev. 2013 Mar 28(3):CD009191. doi: 10.1002/14651858.CD009191.pub2.
4
The frequency of the ACE I/D polymorphism in South America: a systematic review and meta-analysis.南美洲 ACE I/D 多态性的频率：系统评价和荟萃分析。
Mol Cell Biochem. 2024 Nov;479(11):2955-2972. doi: 10.1007/s11010-023-04923-9. Epub 2024 Feb 3.
5
Relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and systemic lupus erythematosus/lupus nephritis: a systematic review and metaanalysis.血管紧张素转换酶插入/缺失基因多态性与系统性红斑狼疮/狼疮性肾炎的关系：系统评价和荟萃分析。
J Rheumatol. 2012 Apr;39(4):686-93. doi: 10.3899/jrheum.110863. Epub 2012 Feb 15.
6
Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension.血管紧张素I转换酶基因多态性和血管紧张素原基因多态性在原发性高血压血压调节中的作用。
Am J Hypertens. 1998 Feb;11(2):174-83. doi: 10.1016/s0895-7061(97)00402-0.
7
Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension.血管紧张素转换酶（ACE）抑制剂与血管紧张素受体阻滞剂治疗原发性高血压的比较。
Cochrane Database Syst Rev. 2014 Aug 22;2014(8):CD009096. doi: 10.1002/14651858.CD009096.pub2.
8
Increased formation of angiotensin II from angiotensin I in individuals of African descent.在非洲裔个体中，血管紧张素I生成血管紧张素II的过程增强。
J Hypertens. 2025 Aug 1;43(8):1436-1441. doi: 10.1097/HJH.0000000000004068. Epub 2025 Jun 5.
9
Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis.血管紧张素转换酶（ACE）基因第16内含子插入/缺失多态性与特发性复发性自然流产的关系：病例对照研究、系统评价和荟萃分析
Reprod Biomed Online. 2016 Feb;32(2):237-46. doi: 10.1016/j.rbmo.2015.11.003. Epub 2015 Nov 23.
10
Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension.血管紧张素I转换酶基因多态性与原发性高血压患者对卡托普利的急性反应
Am J Hypertens. 1997 Sep;10(9 Pt 1):1064-8. doi: 10.1016/s0895-7061(97)00279-3.

本文引用的文献

1
Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study.血管紧张素转换酶插入/缺失多态性、ACE 活性与 COVID-19：一个颇具争议的假说。一项病例对照研究。
J Med Virol. 2022 Mar;94(3):1050-1059. doi: 10.1002/jmv.27417. Epub 2021 Nov 5.
2
Association between angiotensin converting enzyme gene polymorphism and essential hypertension: A systematic review and meta-analysis.血管紧张素转换酶基因多态性与原发性高血压的相关性：系统评价和荟萃分析。
J Renin Angiotensin Aldosterone Syst. 2021 Jan-Dec;22(1):1470320321995074. doi: 10.1177/1470320321995074.
3
Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.羧肽酶 1 基因多态性对人肝中转哚普利拉激活作用及健康志愿者药代动力学和药效学的影响。
Clin Transl Sci. 2021 Jul;14(4):1380-1389. doi: 10.1111/cts.12989. Epub 2021 Mar 4.
4
ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role.血管紧张素转换酶基因插入/缺失多态性与新型冠状病毒肺炎合并急性肺栓塞：一种潜在的易感作用
Front Med (Lausanne). 2021 Jan 21;7:631148. doi: 10.3389/fmed.2020.631148. eCollection 2020.
5
Association of angiotensin converting enzyme gene insertion/deletion polymorphism with essential hypertension in south Indian population.血管紧张素转换酶基因插入/缺失多态性与印度南部人群原发性高血压的关联。
Genes Dis. 2016 Mar 25;3(2):159-163. doi: 10.1016/j.gendis.2016.03.001. eCollection 2016 Jun.
6
The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease.血管紧张素转换酶插入/缺失多态性单独及与伴随危险因素共同作用对冠状动脉疾病的影响。
Clin Appl Thromb Hemost. 2018 Jan;24(1):157-163. doi: 10.1177/1076029616679505. Epub 2016 Nov 28.
7
Angiotensinogen (AGT) M235T, AGT T174M and Angiotensin-1-Converting Enzyme (ACE) I/D Gene Polymorphisms in Essential Hypertension: Effects on Ramipril Efficacy.原发性高血压中血管紧张素原（AGT）M235T、AGT T174M及血管紧张素转换酶（ACE）I/D基因多态性：对雷米普利疗效的影响
Open Cardiovasc Med J. 2015 Dec 29;9:118-26. doi: 10.2174/1874192401509010118. eCollection 2015.
8
Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients.保加利亚患者中内皮型一氧化氮合成与肾素-血管紧张素-醛固酮系统多态性与冠状动脉疾病发生的关联
Genet Test Mol Biomarkers. 2016 Feb;20(2):67-73. doi: 10.1089/gtmb.2015.0195. Epub 2015 Dec 15.
9
ACE insertion/deletion polymorphism and diabetic nephropathy: clinical implications of genetic information.血管紧张素转换酶插入/缺失多态性与糖尿病肾病：遗传信息的临床意义
J Diabetes Res. 2014;2014:846068. doi: 10.1155/2014/846068. Epub 2014 Dec 23.
10
Correlation of renin angiotensin system (RAS) candidate gene polymorphisms with response to Ramipril in patients with essential hypertension.原发性高血压患者肾素血管紧张素系统（RAS）候选基因多态性与雷米普利反应的相关性
J Postgrad Med. 2015 Jan-Mar;61(1):21-6. doi: 10.4103/0022-3859.147028.

插入/缺失基因多态性与卡托普利在印度尼西亚高血压患者中的疗效相关性。

Correlation of insertion/deletion gene polymorphism with captopril effectiveness in Indonesian hypertensive patients.

机构信息

Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, Bali, Indonesia.

Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.

出版信息

Pharmacogenomics. 2024;25(8-9):357-365. doi: 10.1080/14622416.2024.2375190. Epub 2024 Jul 29.

DOI:10.1080/14622416.2024.2375190
PMID:39069948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11734884/
Abstract

Hypertension is a prevalent health concern in Indonesia, with a high percentage of patients unresponsive to ACE inhibitor treatment. This multicenter case-control study investigated the correlation between ACE I/D and captopril effectiveness in Indonesian hypertensive patients. Hypertensive patients were divided into control (n = 69) and case (n = 73) groups. was identified using PCR and electrophoresis. No significant differences in genotype frequencies or allele distribution were observed. The difference of blood pressure reduction among the three genotypes also lacked statistical significance. is not significantly associated with blood pressure reduction following captopril therapy in Indonesian hypertensive patients. These results underscore the limited predictive utility of in managing hypertension with captopril.

摘要

高血压是印度尼西亚普遍存在的健康问题，很大比例的患者对 ACE 抑制剂治疗无反应。这项多中心病例对照研究调查了 ACE I/D 与卡托普利在印度尼西亚高血压患者中的有效性之间的相关性。高血压患者分为对照组（n=69）和病例组（n=73）。使用 PCR 和电泳法鉴定基因型。基因型频率或等位基因分布无显著差异。三种基因型之间的血压降低差异也没有统计学意义。在印度尼西亚高血压患者中，ACE I/D 与卡托普利治疗后的血压降低无显著相关性。这些结果突出表明，ACE I/D 在使用卡托普利治疗高血压方面的预测作用有限。