Ninth Hospital of Wuhan, Wuhan City, Hubei Province, China.
Department of Endocrinology, Ninth Hospital of Wuhan, Wuhan City, Hubei Province, China.
J Renin Angiotensin Aldosterone Syst. 2021 Jan-Dec;22(1):1470320321995074. doi: 10.1177/1470320321995074.
The current meta-analytic study explored the relation between ACE gene insertion/deletion (I/D), and the risk of EH by reviewing relevant trials so as to determine the association between Angiotensin Converting Enzyme (ACE) gene polymorphism and essential hypertension (EH) susceptibility.
Relevant studies published before May 2019 were collected from the PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP databases.
Fifty-seven studies involving a total of 32,862 patients were included. These studies found that ACE gene D allele was associated with higher EH susceptibility in allelic model, homozygote model, dominant model, and regressive model, and that Asian population with ACE gene D allele showed a higher EH susceptibility in all these models. Moreover, ACE gene D allele was found closely related to a higher EH susceptibility in the subgroups of HWE, NO HWE, Caucasian population, and Mixed population, with the majority being males in allelic model, homozygote model, and regressive model and the majority being females in allelic model.
ACE gene D allele is associated with an overall higher EH susceptibility, which is confirmed in the subgroup analysis of Asian population, HWE, NO HWE, Caucasian population, and Mixed population.
本荟萃分析研究通过回顾相关试验，探讨了 ACE 基因插入/缺失（I/D）与 EH 风险之间的关系，以确定血管紧张素转换酶（ACE）基因多态性与原发性高血压（EH）易感性之间的关联。
从 PubMed、Cochrane、Embase、CNKI、VANFUN 和 VIP 数据库中收集了截至 2019 年 5 月之前发表的相关研究。
共纳入 57 项研究，总计 32862 例患者。这些研究发现 ACE 基因 D 等位基因在等位基因模型、纯合子模型、显性模型和回归模型中与更高的 EH 易感性相关，且亚洲人群 ACE 基因 D 等位基因在所有这些模型中均显示出更高的 EH 易感性。此外，ACE 基因 D 等位基因与 HWE、NO HWE、白种人群和混合人群中的 EH 易感性较高密切相关，在等位基因模型、纯合子模型和回归模型中大多数为男性，在等位基因模型中大多数为女性。
ACE 基因 D 等位基因与整体较高的 EH 易感性相关，在亚组分析中，包括亚洲人群、HWE、NO HWE、白种人群和混合人群，这一结论得到了证实。
