Daume Jonathan, Kamiński Jan, Salimpour Yousef, Anderson William S, Valiante Taufik A, Mamelak Adam N, Rutishauser Ueli
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.
bioRxiv. 2024 Jul 16:2024.07.15.603630. doi: 10.1101/2024.07.15.603630.
Working Memory (WM) and Long-Term Memory (LTM) are often viewed as separate cognitive systems. Little is known about how these systems interact when forming memories. We recorded single neurons in the human medial temporal lobe while patients maintained novel items in WM and a subsequent recognition memory test for the same items. In the hippocampus but not the amygdala, the level of WM content-selective persist activity during WM maintenance was predictive of whether the item was later recognized with high confidence or forgotten. In contrast, visually evoked activity in the same cells was not predictive of LTM formation. During LTM retrieval, memory-selective neurons responded more strongly to familiar stimuli for which persistent activity was high while they were maintained in WM. Our study suggests that hippocampal persistent activity of the same cell supports both WM maintenance and LTM encoding, thereby revealing a common single-neuron component of these two memory systems.
工作记忆（WM）和长期记忆（LTM）通常被视为独立的认知系统。对于这些系统在形成记忆时如何相互作用，我们知之甚少。我们在人类内侧颞叶记录单个神经元的活动，同时让患者在工作记忆中保持新的项目，并随后对相同项目进行识别记忆测试。在海马体而非杏仁核中，工作记忆维持期间工作记忆内容选择性持续活动的水平可预测该项目随后是被高置信度识别还是被遗忘。相比之下，同一细胞中的视觉诱发活动并不能预测长期记忆的形成。在长期记忆检索期间，记忆选择性神经元对熟悉刺激的反应更强，这些刺激在工作记忆维持期间的持续活动较高。我们的研究表明，同一细胞的海马体持续活动支持工作记忆维持和长期记忆编码，从而揭示了这两个记忆系统共同的单神经元成分。
