人参皂苷Rb1通过调节CPT1A去乙酰化来抑制肩袖撕裂后的肌内脂肪浸润。
Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.
作者信息
Yin Yuesong, Wang Zili, Yang Yian, Shen Minren, Hu Hai, Chen Chuanshun, Zhou Hecheng, Li Zheng, Wu Song
机构信息
Department of Orthopaedics, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha 410013, China.
Department of Oncology, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha 410013, China.
出版信息
iScience. 2024 Jun 20;27(7):110331. doi: 10.1016/j.isci.2024.110331. eCollection 2024 Jul 19.
Fat infiltration (FI) in the rotator cuff muscle is associated with poor clinical outcomes and failed repair of rotator cuff tears (RCTs) in patients. In this study, we aimed to investigate the function of ginsenoside Rb1 in inhibiting FI in muscles after RCT and its underlying molecular mechanism. After TT modeling, mice treated with Rb1 for 6 weeks showed lower FI in the SS muscle compared with mice in the control groups and those treated with other ginsenoside components. Mechanically, Rb1 binds to the NAD+ domain of SIRT1, activating its expression and enzyme activity. This activation stimulates the deacetylation of CPT1A at site K195, thereby promoting fatty acid β-oxidation in adipocyte cells and improving lipolysis. These findings suggest that Rb1 is a potential therapeutic component for improving the outcomes of patients with RCTs.
肩袖肌中的脂肪浸润（FI）与患者临床预后不良及肩袖撕裂（RCT）修复失败相关。在本研究中，我们旨在探究人参皂苷Rb1在抑制RCT后肌肉中FI的作用及其潜在分子机制。造模后，与对照组小鼠及用其他人参皂苷成分处理的小鼠相比，用Rb1处理6周的小鼠冈下肌中的FI更低。机制上，Rb1与SIRT1的NAD+结构域结合，激活其表达及酶活性。这种激活刺激CPT1A在K195位点的去乙酰化，从而促进脂肪细胞中的脂肪酸β氧化并改善脂肪分解。这些发现表明，Rb1是改善RCT患者预后的一种潜在治疗成分。
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