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吲哚-3-丙酸通过靶向生长素信号调控侧根发育。

Indole-3-propionic acid regulates lateral root development by targeting auxin signaling in .

作者信息

Sun Yue, Yang Zhisen, Zhang Caoli, Xia Jing, Li Yawen, Liu Xin, Sun Linfeng, Tan Shutang

机构信息

MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Molecular & Cell Biophysics, Hefei National Science Center for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

出版信息

iScience. 2024 Jun 24;27(7):110363. doi: 10.1016/j.isci.2024.110363. eCollection 2024 Jul 19.

DOI:10.1016/j.isci.2024.110363
PMID:39071891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278081/
Abstract

Indole-3-propionic acid (IPA) is known to be a microbe-derived compound with a similar structure to the phytohormone auxin (indole-3-acetic acid, IAA). Previous studies reported that IPA exhibited auxin-like bioactivities in plants. However, the underlying molecular mechanism is not totally understood. Here, we revealed that IPA modulated lateral root (LR) development via auxin signaling in the model plant . Genetic analysis indicated that deficiency of the TIR1/AFB-Aux/IAA-ARF auxin signaling pathway abolished the effects of IPA on regulating LR development. Further biochemical, transcriptomic profiling and cell biological analyses revealed that IPA directly bound to the TIR1/AFB-Aux/IAA coreceptor complex and thus activated downstream gene expression. Therefore, our work revealed that IPA is a potential signaling molecule that modulates plant growth and development by targeting the TIR1/AFB-Aux/IAA-mediated auxin signaling pathway, providing potential insights into root growth regulation in plants.

摘要

吲哚-3-丙酸（IPA）是一种微生物衍生的化合物，其结构与植物激素生长素（吲哚-3-乙酸，IAA）相似。先前的研究报道，IPA在植物中表现出类似生长素的生物活性。然而，其潜在的分子机制尚未完全了解。在这里，我们揭示了IPA通过生长素信号通路调节模式植物的侧根发育。遗传分析表明，TIR1/AFB-Aux/IAA-ARF生长素信号通路的缺陷消除了IPA对侧根发育的调节作用。进一步的生化、转录组分析和细胞生物学分析表明，IPA直接与TIR1/AFB-Aux/IAA共受体复合物结合，从而激活下游基因表达。因此，我们的研究揭示了IPA是一种潜在的信号分子，它通过靶向TIR1/AFB-Aux/IAA介导的生长素信号通路来调节植物的生长发育，为植物根系生长调控提供了潜在的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/4adc97f29696/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/40cebd5f9e7e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/fd54805c8d27/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/523307dd2533/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/587e1452e3c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/38cd41935cab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/1f1b3001b168/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/4adc97f29696/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/40cebd5f9e7e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/fd54805c8d27/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/523307dd2533/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/587e1452e3c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/38cd41935cab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/1f1b3001b168/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a94/11278081/4adc97f29696/gr6.jpg

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