三种可能用于诊断胃癌的生物标志物：miR-362-3p、miR-362-5p 和 miR-363-5p。
Three possible diagnostic biomarkers for gastric cancer: miR-362-3p, miR-362-5p and miR-363-5p.
机构信息
Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Medical School Department of Biochemistry & Molecular Medicine, Université de Montréal, Montreal, Québec.
出版信息
Biomark Med. 2024;18(10-12):567-579. doi: 10.1080/17520363.2024.2352419. Epub 2024 Jul 29.
Abstract
MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and some bioinformatics tools were utilized for analyzing the target genes and possible molecular pathways in which these miRNAs participate. There was a significant overexpression of the miRNAs in GC cells and an outstanding correlation between their overexpression with some clinicopathological features of the patients.
摘要
微小 RNA 可以作为早期胃癌 (GC) 诊断的生物标志物。本研究评估了 miR-362-3p、miR-362-5p 和 miR-363-5p 的表达水平，作为 GC 的潜在生物标志物。通过定量实时逆转录 PCR (qRT-PCR) 分析了 90 对 GC 和相邻正常组织样本中 miRNA 的表达水平，并利用一些生物信息学工具分析了这些 miRNA 可能参与的靶基因和分子途径。GC 细胞中 miRNA 表达显著上调，其过表达与患者的一些临床病理特征显著相关。
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